NDLI: Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of <b>HU-210</b> and <b>HU-211</b> as novel candidate PET tracers

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Organic & Biomolecular Chemistry Vol - 15 Issue - 8

Organic & Biomolecular Chemistry Vol - 15 Issue - 7

Organic & Biomolecular Chemistry Vol - 15 Issue - 6

Organic & Biomolecular Chemistry Vol - 15 Issue - 5

Organic & Biomolecular Chemistry Vol - 15 Issue - 4

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Organic & Biomolecular Chemistry Vol -9

Organic & Biomolecular Chemistry Vol -8

Organic & Biomolecular Chemistry Vol -7

Organic & Biomolecular Chemistry Vol -6

Organic & Biomolecular Chemistry Vol -5

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Organic & Biomolecular Chemistry Vol -2

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

Content Provider	Royal Society of Chemistry (RSC)
Author	Marwick, Katie F. M. Spinaci, Andrea Piras, Monica Pertwee, Roger G. Zanda, Matteo Hardingham, Giles E. Wyllie, David J. A. Zanato, Chiara Pelagalli, Alessia Dall'Angelo, Sergio
Copyright Year	2017
Abstract	We report the synthesis of terminally fluorinated HU-210 and HU-211 analogues (HU-210F and HU-211F, respectively) and their biological evaluation as ligands of cannabinoid receptors (CB1 and CB2) and N-methyl D-aspartate receptor (NMDAR). [18F]-labelled HU-210F was radiosynthesised from the bromo-substituted precursor. In vitro assays showed that both HU-210F and HU-211F retain the potent pharmacological profile of HU-210 and HU-211, suggesting that [18F]-radiolabelled HU-210F and HU-211F could have potential as PET tracers for in vivo imaging.
Starting Page	2086
Ending Page	2096
Page Count	11
File Format	HTM / HTML PDF
ISSN	14770520
Volume Number	15
Issue Number	9
Journal	Organic & Biomolecular Chemistry
DOI	10.1039/c6ob02796b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Estrogen receptor Cannabinoid receptor Cannabinoid receptor type 1 Aspartic acid Positron emission tomography HU-210 Dexanabinol Isotopic labeling
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Physical and Theoretical Chemistry

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