NDLI: Luminescent quantum clusters of gold in transferrin family protein, lactoferrin exhibiting FRET

Content Provider	Royal Society of Chemistry (RSC)
Author	Xavier, Paulrajpillai Lourdu Verma, Pramod Kumar Pal, Samir Kumar Pradeep, Thalappil Chaudhari, Kamalesh
Copyright Year	2010
Abstract	We report the synthesis of highly luminescent, water soluble quantum clusters (QCs) of gold, which are stabilized by an iron binding transferrin family protein, lactoferrin (Lf). The synthesized AuQC@Lf clusters were characterized using UV-Visible spectroscopy, X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), photoluminescence (PL), matrix assisted laser desorption ionization mass spectrometry (MALDI-MS), FTIR spectroscopy and circular dichroism (CD) spectroscopy along with picosecond-resolved lifetime measurements. Detailed investigations with FTIR and CD spectroscopy have revealed changes in the secondary structure of the protein in the cluster. We have also studied Förster resonance energy transfer (FRET) occurring between the protein and the cluster. The ability of the clusters to sense cupric ions selectively at ppm concentrations was tested. The stability of clusters in widely varying pH conditions and their continued luminescence make it feasible for them to be used for intracellular imaging and molecular delivery, particularly in view of Lf protection.
Starting Page	2769
Ending Page	2776
Page Count	8
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	2
Issue Number	12
Journal	Nanoscale
DOI	10.1039/c0nr00377h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spectroscopy Förster resonance energy transfer Transferrin Photoluminescence Luminescence Photoemission spectroscopy Biomolecular structure Quantum tunnelling Protein Circular dichroism Lactoferrin Ultraviolet\u2013visible spectroscopy Transmission electron microscopy Ionization Laser PH Extracellular matrix Mass spectrometry X-ray photoelectron spectroscopy
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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View Online PAPER www.rsc.org/nanoscale Nanoscale Luminescent quantum clusters of gold in transferrin family protein, lactoferrin exhibiting FRET† Paulrajpillai Lourdu Xavier, a Kamalesh Chaudhari, b Pramod Kumar Verma, c Samir Kumar Pal c (2011)

Luminescent quantum clusters of gold in exhibiting FRET† (2010)

Luminescent quantum clusters of gold in exhibiting FRET† (2010)

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Luminescent quantum clusters of gold in transferrin family protein, lactoferrin exhibiting FRET

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View Online PAPER www.rsc.org/nanoscale Nanoscale Luminescent quantum clusters of gold in transferrin family protein, lactoferrin exhibiting FRET† Paulrajpillai Lourdu Xavier, a Kamalesh Chaudhari, b Pramod Kumar Verma, c Samir Kumar Pal c (2011)

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