NDLI: Mitotic trafficking of silicon microparticles

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Mitotic trafficking of silicon microparticles

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Back matter

Back cover

Nanoscale Vol - 1 Issue - 1

Mitotic trafficking of silicon microparticles

Content Provider	Royal Society of Chemistry (RSC)
Author	Tasciotti, Ennio Serda, Rita E. Godin, Biana Ferrari, Mauro Liu, XueWu Ferrati, Silvia
Copyright Year	2009
Abstract	Multistage carriers were recently introduced by our laboratory, with the concurrent objectives of co-localized delivery of multiple therapeutic agents, the “theranostic” integration of bioactive moieties with imaging contrast, and the selective, potentially personalized bypassing of the multiplicity of biological barriers that adversely impact biodistribution of vascularly injected particulates. Mesoporous (“nanoporous”) silicon microparticles were selected as primary carriers in multi-stage devices, with targets including vascular endothelia at pathological lesions. The objective of this study was to evaluate biocompatibility of mesoporous silicon microparticles with endothelial cells using in vitroassays with an emphasis on microparticle compatibility with mitotic events. We observed that vascular endothelial cells, following internalization of silicon microparticles, maintain cellular integrity, as demonstrated by cellular morphology, viability and intact mitotic trafficking of vesicles bearing silicon microparticles. The presence of gold or iron oxide nanoparticles within the porous matrix did not alter the cellular uptake of particles or the viability of endothelial cells subsequent to engulfment of microparticles. Endothelial cells maintained basal levels of IL-6 and IL-8 release in the presence of silicon microparticles. This is the first study that demonstrates polarized, ordered partitioning of endosomes based on tracking microparticles. The finding that mitotic sorting of endosomes is unencumbered by the presence of nanoporous silicon microparticles advocates the use of silicon microparticles for biomedical applications.
Starting Page	250
Ending Page	259
Page Count	10
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	1
Issue Number	2
Journal	Nanoscale
DOI	10.1039/b9nr00138g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Interleukin 6 Mesoporous material Iron oxide Biocompatibility Microparticle Extracellular matrix Interleukin 8 Endothelium
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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