NDLI: Monitoring interfacial lectin binding with nanomolar sensitivity using a plasmon field effect transistor

Content Provider	Royal Society of Chemistry (RSC)
Author	Ji, Yiwen Kim, Sung Jin Paik, Younghun Braunschweig, Adam B. Kojori, Hossein Shokri
Copyright Year	2016
Abstract	By immobilizing glycopolymers onto the surface of the recently developed plasmonic field effect transistor (FET), the recognition between lectins and surface-immobilized glycopolymers can be detected over a wide dynamic range (10−10 to 10−4 M) in an environment that resembles the glycocalyx. The binding to the sensor surface by various lectins was tested, and the selectivities and relative binding affinity trends observed in solution were maintained on the sensor surface, and the significantly higher avidities are attributed to cluster-glycoside effects that occur on the surface. The combination of polymer surface chemistry and optoelectronic output in this device architecture produces amongst the highest reported detection sensitivity for ConA. This work demonstrates the benefits that arise from combining emerging device architectures and soft-matter systems to create cutting edge nanotechnologies that lend themselves to fundamental biological studies and integration into point-of-use diagnostics and sensors.
Starting Page	17357
Ending Page	17364
Page Count	8
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	8
Issue Number	39
Journal	Nanoscale
DOI	10.1039/c6nr05544c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Glycocalyx Optoelectronics Field-effect transistor Wide dynamic range Polymer Surface science Ligand (biochemistry)
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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