NDLI: Synthesis, characterization, and biodistribution of multiple <sup>89</sup>Zr-labeled pore-expanded mesoporous silica nanoparticles for PET

Content Provider	Royal Society of Chemistry (RSC)
Author	Reske, Sven Baur, Benjamin Miller, Larissa Solbach, Christoph Winter, Gordon Witulla, Barbara Lindén, Mika
Copyright Year	2014
Abstract	Functional nanoparticles are highly interesting imaging agents for positron emission tomography (PET) due to the possibility of multiple incorporation of positron emitting radionuclides thus increasing the signal strength. Furthermore, long-term nanoparticle biodistribution tests with increased signal-to-noise ratio can be achieved with nanoparticles carrying long-lived isotopes. Mesoporous silica nanoparticles, MSNs, have recently attracted a lot of interest as both imaging agents and carriers for drugs in vitro and in vivo. Here we present results related to the synthesis of PET imageable MSNs carrying the long-lived 89Zr isotope (half-life of 78.4 hours). Here, 89Zr4+ was immobilized through covalent attachment of the complexing agent p-isothiocyanatobenzyldesferrioxamine (DFO-NCS) to large-pore MSNs. Due to the presence of the high DFO content on the MSNs, quantitative 89Zr4+ labeling was achieved within just a few minutes, and no subsequent purification step was needed in order to remove non-complexed 89Zr4+. The stability of the 89Zr-labeled MSNs against leaching of 89Zr4+ was verified for 24 hours. The high signal strength of the 89Zr-DFO-MSNs was evidenced by successful PET imaging using a mouse model at particle loadings one order of magnitude lower than those previously applied in PET-MSN studies. The biodistribution followed the same trends as previously observed for MSNs of different sizes and surface functionalities. Taken together, our results suggest that 89Zr-DFO-MSNs are promising PET imaging agents for long-term in vivo imaging.
Starting Page	4928
Ending Page	4935
Page Count	8
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	6
Issue Number	9
Journal	Nanoscale
DOI	10.1039/c3nr06800e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Isotope Nanoparticle Mesoporous silica Signal-to-noise ratio Covalent bond Half-life DFO Positron emission tomography Laboratory mouse Positron
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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