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Back cover

Nanoscale Vol - 5 Issue - 6

Nanoscale Vol - 5 Issue - 5

Nanoscale Vol - 5 Issue - 4

Nanoscale Vol - 5 Issue - 3

Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration

Content Provider	Royal Society of Chemistry (RSC)
Author	Cheng, Tzu-Yun Huang, Ming-Yuan Wu, Hsi-Chin Chang, Wen-Han Wang, Tzu-Wei Lee, Chao-Hsiung
Copyright Year	2013
Abstract	Traumatic injury or surgery may trigger extensive bleeding. However, conventional hemostatic methods have limited efficacy and may cause surrounding tissue damage. In this study, we use self-assembling peptides (SAPs) and specifically extend fragments of functional motifs derived from fibronectin and laminin to evaluate the capability of these functionalized SAPs in the effect of hemostasis and liver tissue regeneration. From the results, these peptides can self-assemble into nanofibrous network structure and gelate into hydrogel with pH adjustment. In animal studies, the efficacy of hemostasis is achieved immediately within seconds in a rat liver model. The histological analyses by hematoxylin–eosin stain and immunohistochemistry reveal that SAPs with these functionalized motifs significantly enhance liver tissue regeneration. In brief, these SAPs may have potential as pharmacological tools to extensively advance clinical therapeutic applications in hemostasis and tissue regeneration in the field of regenerative medicine.
Starting Page	2734
Ending Page	2744
Page Count	11
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	5
Issue Number	7
Journal	Nanoscale
DOI	10.1039/c3nr33710c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Immunohistochemistry Laminin Wound healing Hemostasis Injury Liver Fibronectin Blood Gel
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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