NDLI: One-step synthesis of monodisperse, water-soluble ultra-small Fe<sub>3</sub>O<sub>4</sub> nanoparticles for potential bio-application

Content Provider	Royal Society of Chemistry (RSC)
Author	Bao, Jian-feng Wang, Dong Ren, Lei Ke, Xue-bin Zhou, Xi Chen, Zhi-wei Chen, Min Yang, An-qi Shen, Li-hua Wang, Yi-xiao
Copyright Year	2013
Abstract	We report that ultra-small, monodisperse, water-dispersible magnetite (Fe3O4) nanoparticles can be synthesized by a facile one-pot approach using trisodium citrate as crystal grain growth inhibitor and stabilizer in polyol solution. The resultant Fe3O4 nanoparticles exhibit an excellent long-term colloidal stability in various buffer solutions without any modification. They are also superparamagnetic at room temperature and their magnetic property relies heavily on their size. Due to the low magnetization and good water-dispersibility, the 1.9 nm-sized Fe3O4 nanoparticles reveal a low r2/r1 ratio of 2.03 (r1 = 1.415 mM−1 s−1, r2 = 2.87 mM−1 s−1), demonstrating that they can be efficient T1 contrast agents. On the other hand, because of the excellent magnetic responsivity, the 13.8 nm-sized Fe3O4 nanoparticles can be readily modified with nitrilotriacetic acid and used to separate the protein simply with the assistance of a magnet. In addition, these Fe3O4 nanoparticles may be useful in other fields, such as hyperthermia treatment of cancer and targeted drug delivery based on their size-dependent magnetic property and excellent stability.
Starting Page	2133
Ending Page	2141
Page Count	9
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	5
Issue Number	5
Journal	Nanoscale
DOI	10.1039/c2nr33840h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dispersity Magnetite Grain growth Trisodium citrate Enzyme inhibitor Superparamagnetism Drug delivery Polyol Hyperthermia Protein Cancer
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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