NDLI: Multilayer nanoparticles with a magnetite core and a polycation inner shell as pH-responsive carriers for drug delivery

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Multilayer nanoparticles with a magnetite core and a polycation inner shell as pH-responsive carriers for drug delivery

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Nanoscale Vol - 2 Issue - 2

Nanoscale Vol -1

Multilayer nanoparticles with a magnetite core and a polycation inner shell as pH-responsive carriers for drug delivery

Content Provider	Royal Society of Chemistry (RSC)
Author	Cao, Youjia Liu, Keliang Yan, Yu Zhang, Hongkai Liu, Xiaozhou Guo, Miao Yan, Husheng
Copyright Year	2010
Abstract	Nanocarriers with multilayer core–shell architecture were prepared by coating a superparamagnetic Fe3O4 core with a triblock copolymer. The first block of the copolymer formed the biocompatible outermost shell of the nanocarrier. The second block that contains amino groups and hydrophobic moiety formed the inner shell. The third block bound tightly onto the Fe3O4 core. Chlorambucil (an anticancer agent) and indomethacin (an anti-inflammation agent), each containing a carboxyl group and a hydrophobic moiety, were loaded into the amino-group-containing inner shell by a combination of ionic and hydrophobic interactions. The release rate of the loaded drugs was slow at pH 7.4, mimicking the blood environment, whereas the release rate increased significantly at acidic pH, mimicking the intracellular conditions in the endosome/lysosome. This can be attributed to the disruption of the ionic bond caused by protonation of the carboxylate anion of the drugs and the swelling of the inner shell caused by protonation of the amino groups.
Starting Page	434
Ending Page	441
Page Count	8
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	2
Issue Number	3
Journal	Nanoscale
DOI	10.1039/b9nr00244h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Chlorambucil Carboxylic acid Indometacin Lysosome PH Biocompatibility Ion Superparamagnetism Copolymer Hydrophobe Endosome Ionic bonding
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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