NDLI: What makes cells move: requirements and obstacles for spontaneous cell motility

Please wait, while we are loading the content...

Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima. 2. Molecular organization and structural stability

Quantitative analysis of the dynamic signaling pathway involved in the cAMP mediated induction of l-carnitine biosynthesis in E. coli cultures

An integrated one-step system to extract, analyze and annotate all relevant information from image-based cell screening of chemical libraries

Interplay of heritage and habitat in the distribution of bacterial signal transduction systems

Finding explained groups of time-course gene expression profiles with predictive clustering trees

Predicting protein–protein interaction specificity through the integration of three-dimensional structural information and the evolutionary record of protein domains

Back matter

Back cover

Molecular BioSystems Vol - 6 Issue - 3

Molecular BioSystems Vol - 6 Issue - 2

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

What makes cells move: requirements and obstacles for spontaneous cell motility

Content Provider	Royal Society of Chemistry (RSC)
Author	Hibner, Urszula Roux, Pierre Pawlak, Geraldine Binamé, Fabien
Copyright Year	2010
Abstract	Movement of individual cells and of cellular cohorts, chains or sheets requires physical forces that are established through interactions of cells with their environment. In vivo, migration occurs extensively during embryonic development and in adults during wound healing and tumorigenesis. In order to identify the molecular events involved in cell movement, in vitro systems have been developed. These have contributed to the definition of a number of molecular pathways put into play in the course of migratory behaviours, such as mesenchymal and amoeboid movement. More recently, our knowledge of migratory modes has been enriched by analyses of cells exploring and moving through three-dimensional (3D) matrices. While the cells’ morphologies differ in 2D and 3D environments, the basic mechanisms that put a cellular body into motion are remarkably similar. Thus, in both 2D and 3D, the polarity of the migrating cell is initially defined by a specific subcellular localization of signalling molecules and components of molecular machines required for motion. While the polarization can be initiated either in response to extracellular signalling or be a chance occurrence, it is reinforced and sustained by positive feedback loops of signalling molecules. Second, adhesion to a substratum is necessary to generate forces that will propel the cell engaged in either mesenchymal or ameboid migration. For collective cell movement, intercellular coordination constitutes an additional requirement: a cell cohort remains stationary if individual cells pull in opposite directions. Finally, the availability of space to move into is a general requirement to set cells into motion. Lack of free space is probably the main obstacle for migration of most healthy cells in an adult multicellular organism. Thus, the requirements for cell movement are both intrinsic to the cell, involving coordinated signalling and interactions with molecular machines, and extrinsic, imposed by the physicochemical nature of the environment. In particular, the geometry and stiffness of the support act on a range of signalling pathways that induce specific cell migratory responses. These issues are discussed in the present review in the context of published work and our own data on collective migration of hepatocyte cohorts.
Starting Page	648
Ending Page	661
Page Count	14
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	6
Issue Number	4
Journal	Molecular BioSystems
DOI	10.1039/b915591k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Hepatocyte Amoeboid movement UEM Edgenta Multicellular organism Stiffness Carcinogenesis Three-dimensional space
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cooperative cell motility during tandem locomotion of amoeboid cells.

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

Computational Studies of Amoeboid Cell Motility in Three-dimensional Matrices

Spontaneous transitions between amoeboid and keratocyte-like modes of migration

Contact-controlled amoeboid motility induces dynamic cell trapping in 3D-microstructured surfaces

Three-dimensional hydrogel is suitable for targeted investigation of amoeboid migration of glioma cells.

Cooperative cell motility during tandem locomotion of amoeboid cells

A computational model of amoeboid cell motility in the presence of obstacles.

An evolutionary perspective on cell migration: Digging for the roots of amoeboid motility

What makes cells move: requirements and obstacles for spontaneous cell motility

Similar Documents

Cooperative cell motility during tandem locomotion of amoeboid cells.

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

Computational Studies of Amoeboid Cell Motility in Three-dimensional Matrices

Spontaneous transitions between amoeboid and keratocyte-like modes of migration

Contact-controlled amoeboid motility induces dynamic cell trapping in 3D-microstructured surfaces

Three-dimensional hydrogel is suitable for targeted investigation of amoeboid migration of glioma cells.

Cooperative cell motility during tandem locomotion of amoeboid cells

A computational model of amoeboid cell motility in the presence of obstacles.

An evolutionary perspective on cell migration: Digging for the roots of amoeboid motility

What makes cells move: requirements and obstacles for spontaneous cell motility