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Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

PerR vs OhrR: selective peroxide sensing in Bacillus subtilis

Content Provider	Royal Society of Chemistry (RSC)
Author	Duarte, Victor Latour, Jean-Marc
Copyright Year	2010
Abstract	Bacteria adapt to elevated levels of reactive oxygen species (ROS) by increasing the expression of detoxification enzymes and repair proteins. These defences are regulated by transcription factors that activate specific genes in response to ROS. In Bacillus subtilis, the adaptive response to peroxide stress is mainly under control of three proteins: σB, PerR and OhrR. σB is a general stress response transcription factor. PerR is a dimeric zinc protein with a regulatory site that coordinates either a Fe2+ or a Mn2+ metal ion. In the presence of iron, PerR mediates strong induction of the perRregulon in response to hydrogen peroxide (H2O2). In contrast to PerR, the OhrR protein is weakly activated by H2O2 but it shows a much higher reactivity for organic hydroperoxides. OhrR controls the expression of a thiol-dependent peroxidase that reduces organic hydroperoxides into their corresponding alcohols. In this review we emphasis peroxide sensing mechanisms for both proteins, focusing on recent biochemical and structural data.
Starting Page	316
Ending Page	323
Page Count	8
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	6
Issue Number	2
Journal	Molecular BioSystems
DOI	10.1039/b915042k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PerR Reactive oxygen species Hydrogen peroxide Mathematical induction Bacillus Ion Peroxidase Transcription factor Zinc Protein
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Redox regulation of tumour suppressor protein p53: identification of the sites of hydrogen peroxide oxidation and glutathionylation

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How Microbes Defend Themselves From Incoming Hydrogen Peroxide

Structure and function of the Leptospira interrogans peroxide stress regulator (PerR), an atypical PerR devoid of a structural metal-binding site

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The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury

Biochemical Characterization of the Structural Zn2+ Site in the Bacillus subtilis Peroxide Sensor PerR

PerR vs OhrR: selective peroxide sensing in Bacillus subtilis

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Transcription Factors That Defend Bacteria Against Reactive Oxygen Species

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PerR vs OhrR: selective peroxide sensing in Bacillus subtilis