NDLI: Genome-scale reconstruction of the metabolic network in Yersinia pestis, strain 91001

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Splicing of mRNA precursors: the role of RNAs and proteins in catalysis

Structure and mechanism of β-hairpin antimicrobial peptides in lipid bilayers from solid-state NMR spectroscopy

Fast predictions of thermodynamics and kinetics of protein–protein recognition from structures: from molecular design to systems biology

Functional models for large-scale gene regulation networks: realism and fiction

Moonlighting proteins—an update

Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

Receptor-independent modulation of reconstituted Gα_i protein mediated by liposomes

Genome-scale reconstruction of the metabolic network in Yersinia pestis, strain 91001

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Protein lethality investigated in terms of long range dynamical interactions

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Genome-scale reconstruction of the metabolic network in Yersinia pestis, strain 91001

Content Provider	Royal Society of Chemistry (RSC)
Author	Navid, Ali Almaas, Eivind
Copyright Year	2009
Abstract	The gram-negative bacterium Yersinia pestis, the aetiological agent of bubonic plague, is one of the deadliest pathogens known to man. Despite its historical reputation, plague is a modern disease which annually afflicts thousands of people. Public safety considerations greatly limit clinical experimentation on this organism and thus development of theoretical tools to analyze the capabilities of this pathogen is of utmost importance. Here, we report the first genome-scale metabolic model of Yersinia pestis biovar Mediaevalis based both on its recently annotated genome, and physiological and biochemical data from the literature. Our model demonstrates excellent agreement with Y. pestis’ known metabolic needs and capabilities. Since Y. pestis is a meiotrophic organism, we have developed CryptFind, a systematic approach to identify all candidate cryptic genes responsible for known and theoretical meiotrophic phenomena. In addition to uncovering every known cryptic gene for Y. pestis, our analysis of the rhamnosefermentation pathway suggests that betB is the responsible cryptic gene. Despite all of our medical advances, we still do not have a vaccine for bubonic plague. Recent discoveries of antibiotic resistant strains of Yersinia pestis coupled with the threat of plague being used as a bioterrorism weapon compel us to develop new tools for studying the physiology of this deadly pathogen. Using our theoretical model, we can study the cell’s phenotypic behavior under different circumstances and identify metabolic weaknesses that may be harnessed for the development of therapeutics. Additionally, the automatic identification of cryptic genes expands the usage of genomic data for pharmaceutical purposes.
Starting Page	368
Ending Page	375
Page Count	8
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	5
Issue Number	4
Journal	Molecular BioSystems
DOI	10.1039/b818710j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Gene Antibiotics Yersinia Genomics Vaccine Physiology Gram-negative bacteria Pathogen Bioterrorism Bubonic plague
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Genome-scale reconstruction of the metabolic network in Yersinia pestis, strain 91001

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Genome-scale reconstruction of the metabolic network in Yersinia pestis, strain 91001

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Genome-scale reconstruction of the metabolic network in Yersinia pestis, strain 91001

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Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.

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