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An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets

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Molecular BioSystems Vol - 12 Issue - 6

Molecular BioSystems Vol -9

Molecular BioSystems Vol -8

Molecular BioSystems Vol -7

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets

Content Provider	Royal Society of Chemistry (RSC)
Author	Papageorgiou, Louis Loukatou, Styliani Maroulis, Dimitrios Vlachakis, Dimitrios Sofia, Kossida
Copyright Year	2016
Abstract	The rate of Flaviviridae family virus infections worldwide has increased dramatically in the last few years. In addition, infections caused by arthropod vector viruses including Hepatitis C, West Nile, Dengue fever, Yellow fever and Japanese encephalitis are emerging throughout the world. Based on a recent taxon update, the Flaviviridae family comprises four main genera; Flavivirus, Hepacivirus, Pestivirus and a recent genus Pegivirus. Although the new scientific classification plays a key role in providing useful information about the relationships between viruses, many new documented viruses remain unclassified. Furthermore, based on the different results of several studies the classification is unclear. In an effort to provide more insights into the classification of viruses, a holistic evolutionary study of the two viral enzymes NS3 helicase and NS5 RNA-dependent RNA polymerase (RdRp) has been conducted in this study. These two viral enzymes are very crucial for the inhibition of viruses due to the fact that they are involved in the survival, proliferation and transmission of viruses. The main goal of this study is the presentation of two novel updated phylogenetic trees of the enzymes NS3 helicase and NS5 RdRp as a reliable phylogeny “map” to correlate the information of the closely related viruses and identify new possible targets for the Flaviviridae family virus inhibition. Despite the earliest trials for drugs against Flaviviridae related viruses, no antiviral drug vaccine has been available to date. Therefore there is an urgent need for research towards the development of efficient antiviral agents.
Starting Page	2080
Ending Page	2093
Page Count	14
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	12
Issue Number	7
Journal	Molecular BioSystems
DOI	10.1039/c5mb00706b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Pestivirus Helicase Euclidean vector Dengue fever RNA-dependent RNA polymerase Phylogenetic tree Taxon Arthropod International Committee on Taxonomy of Viruses Vaccine Antiviral drug Flavivirus NS3 (HCV) Virus Polymerase Nile Phylogenetics West Nile Hepatitis C Flaviviridae Hepacivirus Pegivirus Yellow fever Japanese encephalitis
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets

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