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Contents and Chemical Biology

Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species

Protein kinase CK2 as a druggable target

Small molecule enhancers of autophagy for neurodegenerative diseases

Surveying the damage: the challenges of developing nucleic acid biomarkers of inflammation

Targeting transcription factors for therapeutic benefit

Linking the kinome and phosphorylome—a comprehensive review of approaches to find kinase targets

Peptide mass fingerprinting using isotopically encoded photo-crosslinking amino acids

Transcriptomic analysis of Saccharomyces cerevisiae physiology in the context of galactose assimilation perturbations

Fluorescent resonance energy transfer (FRET) based detection of a multiplex ligation-dependent probe amplification assay (MLPA) product

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Linking the kinome and phosphorylome—a comprehensive review of approaches to find kinase targets

Content Provider	Royal Society of Chemistry (RSC)
Author	Sopko, Richelle Andrews, Brenda J.
Copyright Year	2008
Abstract	Protein phosphorylation is associated with most cell signaling and developmental processes in eukaryotes. Despite the vast extent of the phosphoproteome within the cell, connecting specific kinases with relevant targets remains a significant experimental frontier. The challenge of linking kinases and their substrates reflects the complexity of kinase function. For example, kinases tend to exert their biological effects through supernumerary, redundant phosphorylation, often on multiple protein complex components. Although these types of phosphorylation events are biologically significant, those kinases responsible are often difficult to identify. Recent methods for global analysis of proteinphosphorylation promise to substantially accelerate efforts to map the dynamic phosphorylome. Here, we review both conventional methods to identify kinase targets and more comprehensive genomic and proteomic approaches to connect the kinome and phosphorylome.
Starting Page	920
Ending Page	933
Page Count	14
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	4
Issue Number	9
Journal	Molecular BioSystems
DOI	10.1039/b801724g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Kinome Phosphorylation Protein kinase Cell signaling Protein
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling*

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Linking the kinome and phosphorylome—a comprehensive review of approaches to find kinase targets

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