NDLI: The Ca<sup>2+</sup>-ATPase pump facilitates bidirectional proton transport across the sarco/endoplasmic reticulum

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Molecular BioSystems Vol - 13 Issue - 3

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The Ca²⁺-ATPase pump facilitates bidirectional proton transport across the sarco/endoplasmic reticulum

Content Provider	Royal Society of Chemistry (RSC)
Author	Espinoza-Fonseca, L. Michel
Copyright Year	2017
Abstract	Ca2+ transport across the sarco/endoplasmic reticulum (SR) plays an essential role in intracellular Ca2+ homeostasis, signalling, cell differentiation and muscle contractility. During SR Ca2+ uptake and release, proton fluxes are required to balance the charge deficit generated by the exchange of Ca2+ and other ions across the SR. During Ca2+ uptake by the SR Ca2+-ATPase (SERCA), two protons are countertransported from the SR lumen to the cytosol, thus partially compensating for the charge moved by Ca2+ transport. Studies have shown that protons are also transported from the cytosol to the lumen during Ca2+ release, but a transporter that facilitates proton transport into the SR lumen has not been described. In this article we propose that SERCA forms pores that facilitate bidirectional proton transport across the SR. We describe the location and structure of water-filled pores in SERCA that form cytosolic and luminal pathways for protons to cross the SR membrane. Based on this structural information, we suggest mechanistic models for proton translocation to the cytosol during active Ca2+ transport, and into the SR lumen during SERCA inhibition by endogenous regulatory proteins. Finally, we discuss the physiological consequences of SERCA-mediated bidirectional proton transport across the SR membrane of muscle and non-muscle cells.
Starting Page	633
Ending Page	637
Page Count	5
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	13
Issue Number	4
Journal	Molecular BioSystems
DOI	10.1039/c7mb00065k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	ATPase Homeostasis Proton SERCA Thylakoid Endoplasmic reticulum Cytosol
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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The Ca2+-ATPase pump facilitates bidirectional proton transport across the sarco/endoplasmic reticulum

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