NDLI: Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice

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Molecular BioSystems Vol -13

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Toward mobile 3D visualization for structural biologists

Expanding the chemistry of fluorescent protein biosensors through genetic incorporation of unnatural amino acids

Network-based analysis of omics with multi-objective optimization

Cost-effective isobaric tagging for quantitative phosphoproteomics using DiART reagents

Gp10 based-thioetherification (10BASE_d-T) on a displaying library peptide of bacteriophage T7

Activity-based protein profiling of secreted cellulolytic enzyme activity dynamics in Trichoderma reesei QM6a, NG14, and RUT-C30

A fluorogenic probe for β-galactosidase activity imaging in living cells

The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling

Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice

RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal

Binding structures and energies of the human neonatal Fc receptor with human Fc and its mutants by molecular modeling and dynamics simulations

Identification of biomarkers for unstable angina by plasma metabolomic profiling

Solvent interaction analysis of intrinsically disordered proteins in aqueous two-phase systems

Functional and pathway enrichment analysis for integrated regulatory network of high- and low-metastatic lung cancer

Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction

Transcriptomic study of ciprofloxacin resistance in Streptomyces coelicolor A3(2)

Effects of temperature on the dynamics of the LacI-TetR-CI repressilator

Design and biological evaluation of synthetic retinoids: probing length vs. stability vs. activity

Integrated proteomic and metabolomic analysis reveals the NADH-mediated TCA cycle and energy metabolism disorders based on a new model of chronic progressive heart failure

Dissecting the salt dependence of the Tus–Ter protein–DNA complexes by high-throughput differential scanning fluorimetry of a GFP-tagged Tus

Metabonomic investigations of age- and batch-related variations in female NMRI mice using proton nuclear magnetic resonance spectroscopy

PNA as a potential modulator of COL7A1 gene expression in dominant dystrophic epidermolysis bullosa: a physico-chemical study

Transfection activity and the mechanism of pDNA-complexes based on the hybrid of low-generation PAMAM and branched PEI-1.8k

Synergetic regulatory networks mediated by oncogene-driven microRNAs and transcription factors in serous ovarian cancer

Identification and comparative analysis of hepatitis C virus–host cell protein interactions

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Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Lili, Wan Jin, Lu Junping, Zhang Bin, Li Yan, Li Yonglong, Han Genjin, Yang Quanjun, Yang Qi, Yu Cheng, Guo
Copyright Year	2013
Abstract	Cancer cachexia is a complex metabolic syndrome that cannot be fully reversed by conventional nutritional support, and leads to the progressive wasting of body tissues, particularly the loss of lean muscle mass. Formoterol, a highly selective β2-adrenoceptor therapeutic drug, gives potential anabolic responses in the context of skeletal muscles and was widely confirmed to possess anti-cachexia effects. However, the possible metabolic pathways and the metabolite changes that initiate and maintain these anabolic responses remain poorly understood. In the present study, a 1H NMR-metabonomics model was established to investigate the metabolic features of cancer cachexia and the contribution of formoterol to serum metabolites in a mouse model bearing CT26 carcinoma cells. Among the metabolic processes found in serum, the ones associated with cancer are glycolysis and lipid lipolysis. However, the citrate cycle and amino acid metabolism are the major metabolic characteristics of cachexia. Furthermore, formoterol stimulated skeletal muscle growth, increased the body weight and altered the metabolic profile. Amino acids, ketone bodies and citrate cycle metabolites are potential biomarkers associated with these functional pathways. Taking the pathways of cancer cachexia into account, formoterol could regulate the imbalance in glycolysis, the citrate cycle, and in lipid and amino acid metabolism. Collectively, these results indicate that formoterol partially reverses the metabolic disturbances associated with cachexia.
Starting Page	3015
Ending Page	3025
Page Count	11
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	9
Issue Number	12
Journal	Molecular BioSystems
DOI	10.1039/c3mb70134d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Carcinoma Cachexia Ketone bodies Metabolism Syndrome Lipid Lipolysis Citric acid Skeletal muscle Mouse Glycolysis Formoterol Anabolism Cancer
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia

Skeletal muscle adaptations in cachectic, tumor-bearing rats (2003).

Formoterol May Activate Rat Muscle Regeneration During Cancer Cachexia

Cancer cachexia and fat-muscle physiology.

Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia.

Aging Aggravates Cachexia in Tumor-Bearing Mice

Establishment of a mouse model of cancer cachexia with spleen deficiency syndrome and the effects of atractylenolide I.

Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation

A Ketogenic Formula Prevents Tumor Progression and Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice

Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice

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Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia

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