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Molecular BioSystems Vol - 8 Issue - 9

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Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens

Content Provider	Royal Society of Chemistry (RSC)
Author	Galdiero, Stefania Galdiero, Marilena Mansi, Rosalba Vitiello, Mariateresa Tesauro, Diego Morelli, Giancarlo Finamore, Emiliana
Copyright Year	2012
Abstract	Bacterial derived lipoproteins constitute potent macrophage activators in vivo and are effective stimuli, enhancing the immune response especially with respect to low or non-immunogenic compounds. In the present study we have prepared branched lipopeptide constructs in which different (B- and T-cell) epitopes of Herpes simplex virus type 1, derived from glycoproteins B (gB) and D (gD), are linked to a synthetic lipid core. The ability of the lipid core peptide (LCP) constructs (LCP-gB and LCP-gD) to induce cytokine expression and activate the mitogen-activated protein kinase cascade has been evaluated and compared with the behaviour of the isolated epitopes and the lipid core. In this respect, the use of LCP technology coupled with the use of three different gB or gD peptide epitopes in the same branched constructs could represent an interesting approach in order to obtain efficient delivery systems in the development of a synthetic multiepitopic vaccine for the prevention of viral infections.
Starting Page	3166
Ending Page	3177
Page Count	12
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	8
Issue Number	12
Journal	Molecular BioSystems
DOI	10.1039/c2mb25064k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Simplex Virus T cell Cytokine LCP Mitogen-activated protein kinase Vaccine Peptide Lipopeptide Lipid Macrophage
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Monocytic cells: inhibition of nf-b and mitogen-activated protein kinase activation and of synthesis of (2004).

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Cytokine-induced src homology 2 protein (cis) promotes t cell receptor–mediated proliferation and prolongs survival of activated t cells (2000).

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Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens

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Cytokine-induced src homology 2 protein (cis) promotes t cell receptor–mediated proliferation and prolongs survival of activated t cells (2000).

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Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens