NDLI: Six-day selenium supplementation led to either UVA-photoprotection or toxic effects in human fibroblasts depending on the chemical form and dose of Se

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Metallomics Vol - 6 Issue - 8

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Metallomics Vol - 6 Issue - 6

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Six-day selenium supplementation led to either UVA-photoprotection or toxic effects in human fibroblasts depending on the chemical form and dose of Se

Content Provider	Royal Society of Chemistry (RSC)
Author	Hazane-Puch, Florence Arnaud, Josiane Garrel, Catherine Laporte, François Champelovier, Pierre Faure, Patrice Trocmé, Candice
Copyright Year	2014
Abstract	Selenium (Se) is an essential trace element with a narrow safety zone and unclear effects on skin photoageing. The aim of this work was to investigate the photoageing properties of sodium selenite or selenomethionine (SeMet) after a long term (6 days) Se supplementation in normal human skin fibroblasts (NHSF) subjected to ultraviolet-A (UVA) irradiation inducing 30% cell death. The uptake, toxicity and antioxidant effects of sodium selenite and SeMet were compared to better understand their photoageing properties. SeMet uptake was better than sodium selenite and their uptake by fibroblasts was not via an actively transport process. Sodium selenite induced a higher toxicity than SeMet. At 5 μM, sodium selenite inhibited cell proliferation associated with a blockage in the G2 phase and induced DNA fragmentation leading to caspase-3-dependent apoptosis cell death. At low doses (<1 μM), SeMet and sodium selenite induced glutathione peroxidase-1 (GPX1) activity and selenoproteinW1 (SEPW1) transcript expression but metalloproteinase (MMP)-1 was only induced by sodium selenite. SeMet and sodium selenite did not protect NHSFs from UVA-induced cell death. However, SeMet decreased malondialdehyde (MDA) and protected NHSFs from UVA-induced MMP1 and MMP3. We then observed a large difference in terms of photoprotection according to selenium forms. SeMet may be a potential agent for the prevention and treatment of skin photoageing.
Starting Page	1683
Ending Page	1692
Page Count	10
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	6
Issue Number	9
Journal	Metallomics
DOI	10.1039/c4mt00040d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Glutathione peroxidase Sodium selenite MMP1 G2 phase MMP3 MDA Ultraviolet Antioxidant Malondialdehyde Trace element The UpTake DNA fragmentation Caspase 3 Metalloproteinase Selenium Photoprotection Selenomethionine Apoptosis
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Plasma selenium concentration and glutathione peroxidase activity in red blood cells of laying hens fed sodium selenite or zinc-l-selenomethionine.

Effects of Dietary Zinc and Cadmium on Tissue Selenium Concentration and Glutathione Peroxidase Activity in Rats Fed DL-Selenomethionine or Sodium Selenite

Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine

Effect of dietary supplementation with selenium-enriched yeast or sodium selenite on selenium tissue distribution and meat quality in commercial-line turkeys

Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis

Effect of Dietary Selenomethionine Supplementation on Growth Performance, Tissue Se Concentration, and Blood Glutathione Peroxidase Activity in Kid Boer Goats

Selenium and Glutathione Peroxidase Levels in Lambs Receiving Feed Supplemented with Sodium Selenite or Selenomethionine

Comparative study of DL-selenomethionine vs sodium selenite and seleno-yeast on antioxidant activity and selenium status in laying hens.

The Necessity of Dietary Vitamin $B_{6}$ to Selenium Biopotency for Tissue Selenium and Glutathione Peroxidase in Rats

Six-day selenium supplementation led to either UVA-photoprotection or toxic effects in human fibroblasts depending on the chemical form and dose of Se

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Six-day selenium supplementation led to either UVA-photoprotection or toxic effects in human fibroblasts depending on the chemical form and dose of Se