NDLI: Exposure to arsenic and intra-chromosomal instability in blood

Please wait, while we are loading the content...

A comprehensive biological insight of trinuclear copper(ii)–tin(iv) chemotherapeutic anticancer drug entity: in vitro cytotoxicity and in vivo systemic toxicity studies

Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex

Trivalent methylated arsenic metabolites induce apoptosis in human myeloid leukemic HL-60 cells through generation of reactive oxygen species

Colchicine induced intraneuronal free zinc accumulation and dentate granule cell degeneration

Antidiabetic potential of polyoxotungstates: in vitro and in vivo studies

Hepatic metabolic response to restricted copper intake in a Niemann–Pick C murine model

Structural, spectroscopic and functional investigation into Fe-substituted MnSOD from human pathogen Clostridium difficile

Transformed yeast (Schizosaccharomyces pombe) overexpressing rice Tau class glutathione S-transferase (OsGSTU30 and OsGSTU41) shows enhanced resistance to hexavalent chromium

Identification of aluminium transport-related genes via genome-wide phenotypic screening of Saccharomyces cerevisiae

Back cover

Metallomics Vol - 6 Issue - 7

Metallomics Vol - 6 Issue - 6

Metallomics Vol - 6 Issue - 5

Metallomics Vol - 6 Issue - 4

Metallomics Vol - 6 Issue - 3

Metallomics Vol - 6 Issue - 2

Exposure to arsenic and intra-chromosomal instability in blood

Content Provider	Royal Society of Chemistry (RSC)
Author	Wojdacz, Tomasz K. Vahter, Marie Broberg, Karin Bottai, Matteo
Copyright Year	2014
Abstract	The 450k Chip Analysis Methylation Pipeline (ChAMP) is a novel Illumina Infinium HumanMethylation450 BeadChip data processing algorithm that allows the analysis of copy number alterations (CNAs). With this pipeline we evaluated the prevalence of CNAs in peripheral blood leukocyte samples from healthy Argentinean Andean women with varying exposure to inorganic arsenic in drinking water. Arsenic exposure was assessed based on the sum concentrations of metabolites of inorganic arsenic in urine (U-As), which ranged from 10–663 μg L−1 with a median of 185 μg L−1. We used linear regression analysis to elucidate the association between U-As and the prevalence of CNAs. We found that increasing arsenic exposure was positively associated with the frequency of CNAs (p = 0.002), possibly in a dose–response relationship. Adjustment of the regression model for age and BMI of the subjects did not significantly change the effect estimate, although both covariates were significant predictors. Our results suggest that exposure to arsenic increases genomic instability in the form of CNAs.
Starting Page	1387
Ending Page	1389
Page Count	3
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	6
Issue Number	8
Journal	Metallomics
DOI	10.1039/c4mt00128a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Urine Body mass index Andes Arsenic Linear regression Regression analysis Illumina dye sequencing Algorithm White blood cell Dose\u2013response relationship
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes

Arsenic metabolism and thioarsenicals

Assessment of Arsenic Exposure to Human, Concentrations in Tube Well Water and Urine, and Body Mass Index

Alcohol and blood pressure: the INTERSALT study.

The role of glutathione in the metabolism of diphenylarsinic acid in rats

Significant impact of body mass index on the relationship between increased white blood cell count and new-onset diabetes.

Research respiratory cancer and inhaled inorganic arsenic in copper smelters workers: a linear relationship with cumulative exposure that increases with concentration (2008).

Original Contribution Arsenic Exposure During Pregnancy and Size at Birth: A Prospective Cohort Study in Bangladesh (2008)

Urine Dilution Correction Methods Utilizing Urine Creatinine or Specific Gravity in Arsenic Analyses: Comparisons to Blood and Water Arsenic in the FACT and FOX Studies in Bangladesh

Exposure to arsenic and intra-chromosomal instability in blood

Similar Documents

Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes

Arsenic metabolism and thioarsenicals

Assessment of Arsenic Exposure to Human, Concentrations in Tube Well Water and Urine, and Body Mass Index

Alcohol and blood pressure: the INTERSALT study.

The role of glutathione in the metabolism of diphenylarsinic acid in rats

Significant impact of body mass index on the relationship between increased white blood cell count and new-onset diabetes.

Research respiratory cancer and inhaled inorganic arsenic in copper smelters workers: a linear relationship with cumulative exposure that increases with concentration (2008).

Original Contribution Arsenic Exposure During Pregnancy and Size at Birth: A Prospective Cohort Study in Bangladesh (2008)

Urine Dilution Correction Methods Utilizing Urine Creatinine or Specific Gravity in Arsenic Analyses: Comparisons to Blood and Water Arsenic in the FACT and FOX Studies in Bangladesh

Exposure to arsenic and intra-chromosomal instability in blood