NDLI: Gastrins, iron and colorectal cancer

Content Provider	Royal Society of Chemistry (RSC)
Author	Baldwin, Graham S.
Copyright Year	2009
Abstract	This minireview explores the connections between circulating gastrins, iron status and colorectal cancer. The peptide hormone gastrin is a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. Gastrins bind two ferric ions with μM affinity and, in the case of non-amidated forms of the hormone, iron binding is essential for biological activity. The ferric ion ligands have been identified as glutamates 7, 8 and 9 in the 18 amino acidpeptideglycine-extended gastrin. An interaction between gastrin and transferrin was first demonstrated by covalent crosslinking techniques, and has been recently confirmed by surface plasmon resonance. We have therefore proposed that gastrins act as catalysts in the loading of transferrin with iron. Several recent lines of evidence, including the facts that the concentrations of circulating gastrins are increased in mice and humans with the iron overload disease haemochromatosis, and that transferrin saturation positively correlates with circulating gastrin concentrations, suggest that gastrins may be involved in iron homeostasis. In addition the recognition that ferric ions may play an unexpected role in the biological activity of non-amidated gastrins may assist in the development of new therapies for colorectal carcinoma.
Starting Page	370
Ending Page	374
Page Count	5
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	1
Issue Number	5
Journal	Metallomics
DOI	10.1039/b909112m
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Hormone Iron overload Transferrin Carcinoma Colorectal cancer Homeostasis Ion Transferrin saturation Surface plasmon Gastrin Covalent bond Mitogen Surface plasmon resonance
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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