NDLI: Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide

Please wait, while we are loading the content...

Bis(acetylacetonato)-oxovanadium(iv), bis(maltolato)-oxovanadium(iv) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt

Characterization of mercury-containing protein in human plasma

Effect of distal histidines on hydrogen peroxide activation by manganese reconstituted myoglobin

Vanadium compounds modulate PPARγ activity primarily by increasing PPARγ protein levels in mouse insulinoma NIT-1 cells

The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes

Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn₇MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS

Selenoprotein P and selenoprotein M block Zn²⁺-mediated Aβ₄₂ aggregation and toxicity

Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide

PtCl₂(phen) disrupts the metal ions binding to amyloid-β peptide

The effects of EF-Ts and bismuth on EF-Tu in Helicobacter pylori: implications for an elegant timing for the introduction of EF-Ts in the elongation and EF-Tu as a potential drug target

Mercury modulates selenium activity via altering its accumulation and speciation in garlic (Allium sativum)

Structure-oriented bioinformatic approach exploring histidine-rich clusters in proteins

Cellular response of E. coli upon Hg²⁺ exposure – a case study of advanced nuclear analytical approach to metalloproteomics

Effects of metal ions and disulfide bonds on the activity of phosphodiesterase from Trimeresurus stejnegeri venom

Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumoniae

Back cover

Metallomics Vol - 5 Issue - 6

Metallomics Vol - 5 Issue - 5

Metallomics Vol - 5 Issue - 4

Metallomics Vol - 5 Issue - 3

Metallomics Vol - 5 Issue - 2

Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide

Content Provider	Royal Society of Chemistry (RSC)
Author	Liu, Pei Xu, Shi Rehman, Kanwal Zhang, Yan Fang Naranmandura, Hua Chen, Zhe Zhang, Min Wang, Wen Wen
Copyright Year	2013
Abstract	Arsenic trioxide (As2O3) has been recently established as one of the most effective drugs for the treatment of patients with acute promyelocytic leukemia. However, it has exhibited to be less efficient for the non-promyelocytic leukaemia or other types of malignant tumors. The purpose of the present study was to explore new therapeutic strategies based on As2O3 for human multiple myeloma. Here, we first report cryptotanshinone (CPT) and As2O3 synergy for enhanced cytotoxicity in human multiple myeloma U266 cells. In particular, the apoptosis related proteins (e.g., cleaved poly (ADP-ribose) polymerase (PARP), caspase-3 and -9) were significantly increased by the combination treatment (iAsIII + CPT), whereas, the expression of survival proteins such as Bcl-2 and survivin was suppressed, suggesting that the induction of apoptosis through mitochondrial-mediated apoptotic pathway. In addition, there were no appreciable effects observed in cells after exposure to either As2O3 or CPT alone. In order to better understand the molecular mechanism, we further determined the phosphorylation of STAT3, JNK, ERK and p38. Interestingly, phosphorylation of JNK and p38 were remarkably induced by combination treatment, and no significant inhibition of STAT3 or ERK was observed. In addition, induction of apoptosis in human multiple myeloma cells was partially abrogated only by pretreatment with JNK inhibitor and not by p38 inhibitor, suggesting that JNK pathway may play an important role in induction of apoptosis by the combination of iAsIII and CPT. Further studies are needed to evaluate this synergistic anticancer effect in vivo. In the near future, this new approach might be used clinically for multiple myeloma (MM) treatment.
Starting Page	871
Ending Page	878
Page Count	8
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	5
Issue Number	7
Journal	Metallomics
DOI	10.1039/c3mt20272k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Bcl-2 Phosphorylation CPT Leukemia Multiple myeloma STAT3 Caspase Mitogen-activated protein kinase Enzyme inhibitor Arsenic trioxide Cytotoxicity Adenosine diphosphate ribose Polymerase Acute promyelocytic leukemia P38 mitogen-activated protein kinases C-Jun N-terminal kinases Antimony trioxide ERK Apoptosis
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effects of probucol on cell proliferation in human ovarian cancer cells

Involvement of asp-glu-val-asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 cleavage, c-jun n-terminal kinase activation, and subsequent bcl-2 (2000).

"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium.

Synergistic inhibition of leukemia WEHI-3 cell growth by arsenic trioxide and Hedyotis diffusa Willd extract in vitro and in vivo

Novel human neutrophil agonistic properties of arsenic trioxide: involvement of p38 mitogen-activated protein kinase and/or c-jun NH2-terminal MAPK but not extracellular signal-regulated kinases-1/2.

Differential Activation of Extracellular Signal-Regulated Kinase (ERK) 1, ERK2, p38, and c-Jun NH2-Terminal Kinase Mitogen-Activated Protein Kinases

L-Theanine Protects H9C2 Cells from Hydrogen Peroxide-Induced Apoptosis by Enhancing Antioxidant Capability.

p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications

Inhibition of mitogen-activated protein kinase, kinase enhances apoptosis induced by arsenic trioxide in human breast cancer mcf-7 cells.

Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide

Similar Documents

Effects of probucol on cell proliferation in human ovarian cancer cells

Involvement of asp-glu-val-asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 cleavage, c-jun n-terminal kinase activation, and subsequent bcl-2 (2000).

"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium.

Synergistic inhibition of leukemia WEHI-3 cell growth by arsenic trioxide and Hedyotis diffusa Willd extract in vitro and in vivo

Novel human neutrophil agonistic properties of arsenic trioxide: involvement of p38 mitogen-activated protein kinase and/or c-jun NH2-terminal MAPK but not extracellular signal-regulated kinases-1/2.

Differential Activation of Extracellular Signal-Regulated Kinase (ERK) 1, ERK2, p38, and c-Jun NH2-Terminal Kinase Mitogen-Activated Protein Kinases

L-Theanine Protects H9C2 Cells from Hydrogen Peroxide-Induced Apoptosis by Enhancing Antioxidant Capability.

p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications

Inhibition of mitogen-activated protein kinase, kinase enhances apoptosis induced by arsenic trioxide in human breast cancer mcf-7 cells.

Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide