NDLI: Iron-responsive bacterial small RNAs: variations on a theme

Please wait, while we are loading the content...

The molybdoproteome of Starkeya novella– insights into the diversity and functions of molybdenum containing proteins in response to changing growth conditions

Selenite and tellurite form mixed seleno- and tellurotrisulfides with CstR from Staphylococcus aureus

The Porphyromonas gingivalis HmuY haemophore binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner different to iron(iii) protoporphyrin IX

Co(ii)-detection does not follow K_co(_ii₎ gradient: channelling in Co(ii)-sensing

A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans

The BaeSR regulon is involved in defense against zinc toxicity in E. coli

Streptococcus pneumoniae requires iron for its viability and expresses two membrane proteins that bind haemoglobin and haem

Aerobic uranium immobilization by Rhodanobacter A2-61 through formation of intracellular uranium–phosphate complexes

Exposure of Bacillus subtilis to mercury induces accumulation of shorter tRNA^Cys species

Back cover

Metallomics Vol - 5 Issue - 3

Metallomics Vol - 5 Issue - 2

Iron-responsive bacterial small RNAs: variations on a theme

Content Provider	Royal Society of Chemistry (RSC)
Author	Oglesby-Sherrouse, Amanda G. Murphy, Erin R.
Copyright Year	2013
Abstract	For most living organisms, iron is both essential and potentially toxic, making the precise maintenance of iron homeostasis necessary for survival. To manage this paradox, bacteria regulate the acquisition, utilization, and storage of iron in response to its availability. The iron-dependent ferric uptake repressor (Fur) often mediates this iron-responsive regulation by both direct and indirect mechanisms. In 2002, Masse and Gottesman identified a novel target of Fur-mediated regulation in Escherichia coli: a gene encoding a small regulatory RNA (sRNA) termed RyhB. Under conditions of iron-limitation, RyhB is produced and functions to regulate the expression of several target genes encoding iron-utilizing enzymes, iron acquisition systems, and iron storage factors. This pivotal finding provided the missing link between environmental iron-limitation and previously observed decreases in certain iron-dependent metabolic pathways, a phenomenon now referred to as an “iron-sparing” response. The discovery of RyhB opened the door to the rapidly expanding field of bacterial iron-regulated sRNAs, which continue to be identified and described in numerous bacterial species. Most striking are findings that the impact of iron-responsive sRNA regulation often extends beyond iron homeostasis, particularly with regard to production of virulence-associated factors by pathogenic bacteria. This review discusses trends in the collective body of work on iron-regulated sRNAs, highlighting both the regulatory mechanisms they utilize to control target gene expression and the impact of this regulation on basic processes controlling bacterial physiology and virulence.
Starting Page	276
Ending Page	286
Page Count	11
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	5
Issue Number	4
Journal	Metallomics
DOI	10.1039/c3mt20224k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Paradox Gottesman Bacterial small RNA Gene Escherichia coli RyhB Virulence Homeostasis Bacteria Physiology Masse Non-coding RNA
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Iron-Responsive Bacterial Small RNAs: Variations on a Theme

Post-Transcriptional Regulation of RseA by Small RNAs RyhB and FnrS in Escherichia coli

Effect of RyhB Small RNA on Global Iron Use in Escherichia coli (2005)

Small Non-coding RNA RyhB Mediates Persistence to Multiple Antibiotics and Stresses in Uropathogenic Escherichia coli by Reducing Cellular Metabolism

Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance.

The small RNA RyhB contributes to siderophore production and virulence of uropathogenic Escherichia coli.

Bacterial iron–sulfur cluster sensors in mammalian pathogens

Iron and zinc exploitation during bacterial pathogenesis

Micros for microbes: non-coding regulatory RNAs in bacteria

Iron-responsive bacterial small RNAs: variations on a theme

Similar Documents

Iron-Responsive Bacterial Small RNAs: Variations on a Theme

Post-Transcriptional Regulation of RseA by Small RNAs RyhB and FnrS in Escherichia coli

Effect of RyhB Small RNA on Global Iron Use in Escherichia coli (2005)

Small Non-coding RNA RyhB Mediates Persistence to Multiple Antibiotics and Stresses in Uropathogenic Escherichia coli by Reducing Cellular Metabolism

Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance.

The small RNA RyhB contributes to siderophore production and virulence of uropathogenic Escherichia coli.

Bacterial iron–sulfur cluster sensors in mammalian pathogens

Iron and zinc exploitation during bacterial pathogenesis

Micros for microbes: non-coding regulatory RNAs in bacteria

Iron-responsive bacterial small RNAs: variations on a theme