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Metallomics Vol - 5 Issue - 2

Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve

Content Provider	Royal Society of Chemistry (RSC)
Author	Lippard, Stephen J. Trombley, Paul Q. Tomat, Elisa Blakemore, Laura J.
Copyright Year	2013
Abstract	Zinc is a trace element with a multitude of roles in biological systems including structural and cofactor functions for proteins. Although most zinc in the central nervous system (CNS) is protein bound, the CNS contains a pool of mobile zinc housed in synaptic vesicles within a subset of neurons. Such mobile zinc occurs in many brain regions, such as the hippocampus, hypothalamus, and cortex, but the olfactory bulb (OB) contains one of the highest such concentrations in the CNS. Zinc is distributed throughout the OB, with the glomerular and granule cell layers containing the highest levels. Here, we visualize vesicular zinc in the OB using zinc-responsive fluorescent probes developed by one of us. Moreover, we provide the first demonstration that vesicular pools of zinc can be released from olfactory nerve terminals within individual glomeruli by patterned electrical stimulation of the olfactory nerve designed to mimic the breathing cycle in rats. We also provide electrophysiological evidence that elevated extracellular zinc potentiates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated synaptic events. AMPA receptors are required for the synchronous activation of neurons within individual OB glomeruli, and zinc-mediated potentiation leads to enhanced synaptic summation.
Starting Page	208
Ending Page	213
Page Count	6
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	5
Issue Number	3
Journal	Metallomics
DOI	10.1039/c3mt20158a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Granule cell Cerebral cortex Central nervous system Cofactor (biochemistry) Hypothalamus Zinc Protein Trace element AMPA receptor OB Glomerulus (kidney) Olfactory nerve Olfactory bulb Hippocampus
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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