NDLI: Fast and slow versus strong and weak metal–DNA binding: consequences for anti-cancer activity

Content Provider	Royal Society of Chemistry (RSC)
Author	Reedijk, Jan
Copyright Year	2012
Abstract	The binding of transition metal compounds to nucleic acids is discussed in the perspectives of kinetics and their anticancer activity. Kinetics of ligand exchange is primarily determined by the intrinsic properties of the metal ions, and to a lesser degree by the ligands coordinated already to the metal ion. Metal compounds having ligand-exchange rates of the same order of magnitude as cell-division processes, e.g. many Pt(II), Ru(II) and Ru(III) compounds, are in use as chemotherapeutic drugs. Detailed knowledge of ligand exchange in such compounds is important for design of derivative and entirely new compounds. Metal coordination compounds of metal ions with much faster ligand-exchange reactions interact with DNA in a quite different way, namely primarily by compensation of negative charge of the polyanionic chain and are usually not active as anticancer agents. Examples of our recent work are presented in relation with experiments performed by others on new generations of platinum anti-cancer drugs.
Starting Page	628
Ending Page	632
Page Count	5
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	4
Issue Number	7
Journal	Metallomics
DOI	10.1039/c2mt20032e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ligand Interaction DNA Ion Transition metal
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Zinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences

The biological chemistry of the transition metal “transportome” of Cupriavidus metallidurans

The role of vanadium in biology

Transition metals in plant photosynthesis

Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

The missing Zinc: p53 misfolding and cancer

Metal ion binding of the first external loop of DCT1 in aqueous solution

Metal-mediated DNA damage and cell death: mechanisms, detection methods, and cellular consequences

Anti-proliferative and anti-tumor activity of silver(i) compounds

Fast and slow versus strong and weak metal–DNA binding: consequences for anti-cancer activity

Similar Documents

Zinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences

The biological chemistry of the transition metal “transportome” of Cupriavidus metallidurans

The role of vanadium in biology

Transition metals in plant photosynthesis

Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

The missing Zinc: p53 misfolding and cancer

Metal ion binding of the first external loop of DCT1 in aqueous solution

Metal-mediated DNA damage and cell death: mechanisms, detection methods, and cellular consequences

Anti-proliferative and anti-tumor activity of silver(i) compounds

Fast and slow versus strong and weak metal–DNA binding: consequences for anti-cancer activity