NDLI: Effects of chronic chromium(vi) exposure on blood element homeostasis: An epidemiological study

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Tiancheng Cui, Xiaoxing Zhang, Ji Du, Xianmei Jia, Guang Yu, Shanfa Song, Yanshuang
Copyright Year	2012
Abstract	One hundred chromate production workers chronically exposed to low-level of hexavalent chromium [Cr(VI)] and eighty healthy individuals free from Cr exposure were recruited to the study. Personal sampling of airborne Cr was conducted and Cr content was quantified by Flame Atomic Absorption Spectrometry (FAAS). At the end of the sampling shift, blood samples were collected and element concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS) for Cr, Cd, Cu, Mo and Se and inductively coupled plasma atomic emission spectrometry (ICP-AES) for Ca, Fe, Mg and Zn. According to our results, 90% of the chromate production workers were exposed to airborne Cr in a concentration lower than 50 μg m−3, which is the threshold limit value recommended by the American Conference of Governmental Industrial Hygienists and Chinese Ministry of Health. After Cr(VI) exposure, a significant increase in blood Cr, Cd, Fe, Mg, Mo, Se and Zn concentrations was observed, as well as a significant decrease in Ca concentration. A decrease in blood Cu was only observed among female workers. Blood Cr concentrations of the exposed workers (median = 15.68 ng mL−1) was four times higher than that of the controls (median = 3.03 ng mL−1), and significantly correlated with airborne Cr (r = 0.568, P<0.001). In addition, the inter-element correlations exhibited significant differences between the two groups. Our findings of the related health effects suggested that the underlying mechanisms of chronic Cr(VI) exposure on blood element homeostasis might be partly explained by oxidative stress in the body, dysfunction of Fe metabolism and renal injury.
Starting Page	463
Ending Page	472
Page Count	10
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	4
Issue Number	5
Journal	Metallomics
DOI	10.1039/c2mt20051a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxidative stress Cu American Conference of Governmental Industrial Hygienists and Chinese Ministry of Health Mo Inductively coupled plasma Chromium Particulates Homeostasis Inductively coupled plasma atomic emission spectroscopy Inductively coupled plasma mass spectrometry Metabolism Chromate and dichromate
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Simultaneous determination of trace impurities in high-purity chromium metal and chromium disilicide by inductively coupled plasma atomic emission spectrometry after coprecipitation

Classification models based on the level of metals in hair and nails of laryngeal cancer patients: diagnosis support or rather speculation?

Bioimaging of copper alterations in the aging mouse brain by autoradiography, laser ablation inductively coupled plasma mass spectrometry and immunohistochemistry

High precision isotope measurements reveal poor control of copper metabolism in Parkinsonism

Sensitive method for determination of lead by potassium dichromate–lactic acid hydride generation inductively coupled plasma atomic emission spectrometry

Diverse accumulation and distribution of nutrient elements in developing wheat grain studied by laser ablation inductively coupled plasma mass spectrometry imaging

Analysis of zirconium alloys by inductively coupled plasma atomic emission spectrometry

Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics

Characterisation of element profile changes induced by long-term dietary supplementation of zinc in the brain and cerebellum of 3xTg-AD mice by alternated cool and normal plasma ICP-MS

Effects of chronic chromium(vi) exposure on blood element homeostasis: An epidemiological study

Similar Documents

Simultaneous determination of trace impurities in high-purity chromium metal and chromium disilicide by inductively coupled plasma atomic emission spectrometry after coprecipitation

Classification models based on the level of metals in hair and nails of laryngeal cancer patients: diagnosis support or rather speculation?

Bioimaging of copper alterations in the aging mouse brain by autoradiography, laser ablation inductively coupled plasma mass spectrometry and immunohistochemistry

High precision isotope measurements reveal poor control of copper metabolism in Parkinsonism

Sensitive method for determination of lead by potassium dichromate–lactic acid hydride generation inductively coupled plasma atomic emission spectrometry

Diverse accumulation and distribution of nutrient elements in developing wheat grain studied by laser ablation inductively coupled plasma mass spectrometry imaging

Analysis of zirconium alloys by inductively coupled plasma atomic emission spectrometry

Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics

Characterisation of element profile changes induced by long-term dietary supplementation of zinc in the brain and cerebellum of 3xTg-AD mice by alternated cool and normal plasma ICP-MS

Effects of chronic chromium(vi) exposure on blood element homeostasis: An epidemiological study