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Metallomics Vol - 8 Issue - 9

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Fe–oxy adducts of heme–Aβ and heme–hIAPP complexes: intermediates in ROS generation

Content Provider	Royal Society of Chemistry (RSC)
Author	Mukherjee, Soumya Dey, Somdatta Ghosh Seal, Manas
Copyright Year	2016
Abstract	Iron (Fe) is the most abundant transition metal ion in the human body and its role, in the form of heme, has been implicated in Alzheimer's disease (AD) and type 2 diabetes mellitus (T2Dm). Heme binds both amyloid beta (Aβ) and human islet amyloid polypeptide (hIAPP) to form heme–Aβ and heme–hIAPP complexes, respectively, and form reactive oxygen species (ROS) like H2O2, O2˙−etc., which are known to cause oxidative damage. However the intermediates involved during ROS formation have not yet been isolated. In this study the oxygen bound intermediates of both heme–Aβ(1–16) and heme–hIAPP(1–19) have been isolated and characterized using absorption, EPR and resonance Raman (rR) spectroscopy. Fe–O stretches have been found at 575 cm−1 and 577 cm−1 for heme–Aβ(1–16) and heme–hIAPP(1–19) respectively. The oxy intermediates are stable at low temperatures. The isolation of the intermediates reveals a mechanistic pathway of ROS generation through the two heme complexes.
Starting Page	1266
Ending Page	1272
Page Count	7
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	8
Issue Number	12
Journal	Metallomics
DOI	10.1039/c6mt00214e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spectroscopy Reactive oxygen species Hydrogen peroxide Allotropes of oxygen EPR Amylin Ion Transition metal Diabetes mellitus type 2 Amyloid beta Heme Raman Resonance Raman spectroscopy
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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