NDLI: The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis

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The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis

Content Provider	Royal Society of Chemistry (RSC)
Author	Fetherston, Jacqueline D. Perry, Robert D. Bobrov, Alexander G.
Copyright Year	2015
Abstract	Yersinia pestis, the causative agent of bubonic, septicemic and pneumonic plague, encodes a multitude of Fe transport systems. Some of these are defective due to frameshift or IS element insertions, while others are functional in vitro but have no established role in causing infections. Indeed only 3 Fe transporters (Ybt, Yfe and Feo) have been shown to be important in at least one form of plague. The yersiniabactin (Ybt) system is essential in the early dermal/lymphatic stages of bubonic plague, irrelevant in the septicemic stage, and critical in pneumonic plague. Two Mn transporters have been characterized (Yfe and MntH). These two systems play a role in bubonic plague but the double yfe mntH mutant is fully virulent in a mouse model of pneumonic plague. The same in vivo phenotype occurs with a mutant lacking two (Yfe and Feo) of four ferrous transporters. A role for the Ybt siderophore in Zn acquisition has been revealed. Ybt-dependent Zn acquisition uses a transport system completely independent of the Fe-Ybt uptake system. Together Ybt components and ZnuABC play a critical role in Zn acquisition in vivo. Single mutants in either system retain high virulence in a mouse model of septicemic plague while the double mutant is completely avirulent.
Starting Page	965
Ending Page	978
Page Count	14
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	7
Issue Number	6
Journal	Metallomics
DOI	10.1039/c4mt00332b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Critical Role Yersinia Virulence Genetically modified mouse Frameshift mutation Phenotype Zn Siderophore Yfe Septicemic plague ZnuABC Yersiniabactin Pneumonic plague Bubonic plague
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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The Yersinia pestis Siderophore, Yersiniabactin, and the ZnuABC system both contribute to Zinc acquisition and the development of lethal septicemic plague in mice

The Role of Transition Metal Transporters for Iron, Zinc, Manganese, and Copper in the Pathogenesis of Yersinia pestis

Yersinia ironomics: comparison of iron transporters among Yersiniapestis biotypes and its nearest neighbor, Yersinia pseudotuberculosis

The Yfe and Feo Transporters Are Involved in Microaerobic Growth and Virulence of Yersinia pestis in Bubonic Plague

Yersiniabactin iron uptake: mechanisms and role in Yersinia pestis pathogenesis.

Roles of the Yfe and Feo transporters of Yersinia pestis in iron uptake and intracellular growth

Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis

Identification of New Virulence Factors and Vaccine Candidates for Yersinia pestis

Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague.

The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis

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