NDLI: On-chip extrusion of lipid vesicles and tubes through microsized apertures

Content Provider	Royal Society of Chemistry (RSC)
Author	Dittrich, Petra S. Renaud, Philippe Heule, Martin Manz, Andreas
Copyright Year	2006
Abstract	In this work we present the formation of micrometre-sized lipid vesicles and tubes with perfectly homogeneous diameter and extraordinary length. The method is a novel approach for unconventional fabrication of soft-matter microstructured devices based on the combination of top-down and bottom-up fabrication processes. Photolithography techniques are applied to fabricate microsized apertures that provide the requirements to form lipid structures with predictable size and to align and guide the vesicles and tubes in microstructured channels. The formation is facilitated by self-assembly of polar lipids to a lipid membrane that is afterwards forced to undergo a shape transformation by extrusion through a microsized aperture. Both the geometrical restriction by the small aperture and the pressure difference between the top and bottom sides of the aperture determine the form and length of the vesicles and tubes. A strong pressure difference favors the formation of lipid tubes, while a low pressure difference results in the formation of vesicle bunches with spherical and cylindrical shapes. Potential applications for the formed lipid structures could be as microreactors and transport channels as well as in the construction of flexible microfluidic networks.
Starting Page	488
Ending Page	493
Page Count	6
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	6
Issue Number	4
Journal	Lab on a Chip
DOI	10.1039/b517670k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Self-assembly Lipid bilayer Photolithography Aperture Lipid
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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