NDLI: Multi-chamber microfluidic platform for high-precision skin permeation testing

Content Provider	Royal Society of Chemistry (RSC)
Author	Dancik, Y. Alberti, M. Wu, B. Wang, Z. P. Wu, R. G. Sriram, G. Bigliardi, P. L. Feng, Z. Bigliardi-Qi, M. Teo, Y. L.
Copyright Year	2017
Abstract	The established in vitro tool used for testing the absorption and penetration of chemicals through skin in pharmacology, toxicology and cosmetic science is the static Franz diffusion cell. While widespread, Franz cells are relatively costly, low-throughput and results may suffer from poor reproducibility. Microfluidics has the potential to overcome these drawbacks. In this paper, we present a novel microfluidic skin permeation platform and validate it rigorously against the Franz cell by comparing the transport of 3 model chemicals of varying lipophilicity: caffeine, salicylic acid and testosterone. Permeation experiments through silicone membranes show that the chip yields higher sensitivity in permeant cumulative amounts and comparable or lower coefficients of variation. Using a skin organotypic culture, we show that the chip decreases the effect of unstirred water layers that can occur in static Franz cells. The validation reported herein sets the stage for efficient skin permeation and toxicity screening and further development of microfluidic skin-on-chip devices.
Starting Page	1625
Ending Page	1634
Page Count	10
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	17
Issue Number	9
Journal	Lab on a Chip
DOI	10.1039/c6lc01574c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Testosterone Toxicology Permeation Silicone Pharmacology Diffusion Microfluidics Franz Lipophilicity Caffeine
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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