NDLI: A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors

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Inside back cover

Back cover

Lab on a Chip Vol - 17 Issue - 5

Lab on a Chip Vol - 17 Issue - 4

Lab on a Chip Vol - 17 Issue - 3

Lab on a Chip Vol - 17 Issue - 2

Lab on a Chip Vol - 17 Issue - 1

A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors

Content Provider	Royal Society of Chemistry (RSC)
Author	Lee, Miles Vu, Binh Raja, Balakrishnan Mandadi, Vinay Paterson, Andrew S. Buell, Alex Townsend, Blane Brgoch, Jakoah Willson, Richard C.
Copyright Year	2017
Abstract	Through their computational power and connectivity, smartphones are poised to rapidly expand telemedicine and transform healthcare by enabling better personal health monitoring and rapid diagnostics. Recently, a variety of platforms have been developed to enable smartphone-based point-of-care testing using imaging-based readout with the smartphone camera as the detector. Fluorescent reporters have been shown to improve the sensitivity of assays over colorimetric labels, but fluorescence readout necessitates incorporating optical hardware into the detection system, adding to the cost and complexity of the device. Here we present a simple, low-cost smartphone-based detection platform for highly sensitive luminescence imaging readout of point-of-care tests run with persistent luminescent phosphors as reporters. The extremely bright and long-lived emission of persistent phosphors allows sensitive analyte detection with a smartphone by a facile time-gated imaging strategy. Phosphors are first briefly excited with the phone's camera flash, followed by switching off the flash, and subsequent imaging of phosphor luminescence with the camera. Using this approach, we demonstrate detection of human chorionic gonadotropin using a lateral flow assay and the smartphone platform with strontium aluminate nanoparticles as reporters, giving a detection limit of ≈45 pg mL−1 (1.2 pM) in buffer. Time-gated imaging on a smartphone can be readily adapted for sensitive and potentially quantitative testing using other point-of-care formats, and is workable with a variety of persistent luminescent materials.
Starting Page	1051
Ending Page	1059
Page Count	9
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	17
Issue Number	6
Journal	Lab on a Chip
DOI	10.1039/c6lc01167e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Strontium Point-of-care testing Analyte Telemedicine Human chorionic gonadotropin Luminescence Fluorescence Aluminate Gonadotropin Smartphone Workable FC
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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