NDLI: Microfluidic polymer multilayer adsorption on liquid crystal droplets for microcapsule synthesis

Content Provider	Royal Society of Chemistry (RSC)
Author	Priest, Craig Ralston, John Quinn, Anthony Zelikin, Alexander N. Postma, Almar Caruso, Frank
Copyright Year	2008
Abstract	Exploiting microfluidic principles, the potential for chip-based multilayer assembly for the synthesis of polymer microcapsules was investigated. We demonstrate that continuous flow microfluidic multilayer synthesis is a fast, efficient, automated alternative to conventional batch synthesis. In this work, we dispersed liquid crystal (LC) molecules (organic phase) as monodisperse droplets in an aqueous continuous phase containing the primary polymer and a suitable surfactant. The primary polymer was coadsorbed with the surfactant at the organic/aqueous interface, stabilizing the LC droplets against coalescence and providing a template for subsequent polymer adsorption. As the droplet templates are transported through the microfluidic channel, the polymer-containing aqueous continuous phase is selectively withdrawn and replaced with rinse solution, and then with an alternative polymer solution. This selective withdrawal and infusion cycle was repeated to assemble polymer multilayers onto the emulsion droplets. The process was followed using fluorescence microscopy of the fluorescently-labelled polymers at the LC interface and of the flowing polymer solutions during the sequential rinse stages. Cross-linking of the multilayers and removal of the dispersed LC phase resulted in polymer capsules retaining the high monodispersity of the droplet templates. This microfluidic approach significantly reduces the multilayer formation time (to <2 min for 3-layer capsules) of well-defined capsules that are envisaged to have benefits in biomedical applications, including drug delivery and encapsulated biochemical reactions.
Starting Page	2182
Ending Page	2187
Page Count	6
File Format	HTM / HTML PDF
ISSN	14730197
Volume Number	8
Issue Number	12
Journal	Lab on a Chip
DOI	10.1039/b808826h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dispersity Polymer adsorption Emulsion Liquid crystal Microscopy Polymer Drug delivery Surfactant
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Biochemistry Bioengineering Biomedical Engineering

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