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Journal of Materials Chemistry B Vol - 3 Issue - 8

Journal of Materials Chemistry B Vol - 3 Issue - 7

Journal of Materials Chemistry B Vol - 3 Issue - 6

Journal of Materials Chemistry B Vol - 3 Issue - 5

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Effects of plasma-generated nitrogen functionalities on the upregulation of osteogenesis of bone marrow-derived mesenchymal stem cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Shi, Lianxin Shi, Haigang Liu, Na Zhang, Wei Yang, Kun Gu, Bin Wang, Huaiyu Chu, Paul K. Liu, Jun Ji, Junhui
Copyright Year	2015
Abstract	Because of the complex plasma reactions and chemical structures of polymers, it is difficult to construct nitrogen functionalities controllably by plasma technology to attain the desirable biological outcome and hence, their effects on bone cells are sometimes ambiguous and even contradictory. In this study, argon plasma treatment is utilized to convert complex molecular chains into a pyrolytic carbon structure which possesses excellent cytocompatibility. The pyrolytic carbon then serves as a platform to prepare the desired nitrogen functionalities by nitrogen and hydrogen plasma immersion ion implantation. Primary, secondary, and tertiary amine groups can be produced selectively thus minimizing the chemical complexity and creation of multiple types of nitrogen functional groups that are often obtained by other fabrication methods. As a result of the excellent control of the nitrogen functionalities rendered by this plasma technique, the effects of individual nitrogen functionalities on the cytocompatibility and upregulation of bone marrow-derived mesenchymal stem cell (BMSC) osteogenesis can be investigated systematically. The tertiary amine functionalities exhibit the optimal efficiency pertaining to the modulation of the biological response, enhancement of osteogenesis related gene/protein expression, and calcification of the contacted BMSCs. Our results demonstrate that simple plasma technology can be conveniently employed to create the desirable nitrogen functionalities on orthopedic polymers to facilitate osseointegration and mitigate foreign body reactions.
Starting Page	1856
Ending Page	1863
Page Count	8
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	3
Issue Number	9
Journal	Journal of Materials Chemistry B
DOI	10.1039/c4tb02071e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Blood plasma Nitrogen Bone Argon Pyrolysis Carbon Hydrogen Ion Amine Stem cell Gene Protein Calcification Osseointegration
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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