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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Kim, GeunHyung Yeo, MyungGu |
| Copyright Year | 2014 |
| Abstract | Biomedical scaffolds must be mechanically stable and highly porous three-dimensional (3D) structures to allow efficient cell-to-cell and cell-to-substrate interactions, induce blood vessel formation, and transfer oxygen, nutrients, and metabolic waste. A 3D cell-laden hybrid scaffold consisting of a combination of structural synthetic polymers and a cell-laden hydrogel is an outstanding biomedical scaffold due to its controllable mechanical properties, multiple cell loading, and homogeneous cell-distribution within the scaffold. But although this hybrid scaffold is better than conventional scaffolds, some issues must still be overcome. One is the controllability of cell release from the cell-embedded hydrogel. Here, we propose a method to solve this problem using a geometric cell-laden hydrogel. Various cylindrical cell-laden strut sizes (diameter: 100, 200, 400, and 800 μm) using osteoblast-like-cells (MG63) were investigated A diameter of 200 μm was the most attractive to efficiently induce cell release and proliferation based on cell viability and fluorescence analyses. In addition, cell-laden alginate struts (200 and 800 μm) were used to fabricate poly(ε-caprolactone) hybrid scaffolds; the hybrid scaffolds were interlayered with a cell-laden hydrogel (200 μm), demonstrating significantly high osteogenic expression compared to scaffolds laden with 800 μm struts. |
| Starting Page | 6830 |
| Ending Page | 6838 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 2 |
| Issue Number | 39 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c4tb00785a |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Three-dimensional space Blood vessel Oxygen Gel Strut Micrometre Fluorescence Alginic acid Caprolactone |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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