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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Han, Yanqiu Deng, Kerong Xing, Bengang Hou, Zhiyao Lin, Jun Deng, Xiaoran Li, Chunxia Chen, Yinyin Cheng, Ziyong |
| Copyright Year | 2017 |
| Abstract | Near-infrared (NIR) light induced phototherapy has attracted considerable attention due to its deep therapeutic depth. To improve the therapeutic outcome and address non-selective side effects, the combination of complementary phototherapeutic strategies in a single nanoagent with precise targeting ability may provide an effective approach for cancer therapy. Thus we have developed an 808 nm NIR light triggered nanosystem based on IR806 dye functionalized MnFe2O4 (MFO-IR) for synchronous magnetic targeted and magnetic resonance (MR) imaging guided in vivo photodynamic/photothermal synergistic therapy. In this construction strategy, carboxylic acid functionalized NIR dye IR806 is explored as an 808 nm NIR-excited photosensitizer (PS) for the first time, which can also provide a conjugation site for MnFe2O4 nanoparticles (MFO NPs). Here, monodisperse MFO NPs have multiple capacities as dye carriers, targeting ligands, MRI contrast agents and photothermal agents. MFO-IR nanocomposites (NCs) with negligible toxicity present efficient NIR-mediated photothermal damage and ROS cytotoxicity via the relevant in vitro experimental investigations. With ideal magnetic targeting effects and remarkable NIR light-responsive properties, these MFO-IR NCs exhibit high in vivo tumor localization and could destroy subcutaneous solid tumors completely under an external magnetic field and 808 nm laser irradiation. Consequently, this magnetic nanosystem has great potential for simultaneous diagnosis and precise cancer phototherapy. |
| Starting Page | 1803 |
| Ending Page | 1814 |
| Page Count | 12 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 5 |
| Issue Number | 9 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c6tb03233h |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Light therapy Cancer Dye Resonance Magnetic resonance imaging Acid Photosensitizer Dispersity Reactive oxygen species Cytotoxicity Magnetic field Laser |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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