NDLI: Temperature-responsive porous polycaprolactone-based films <i>via</i> surface-initiated ATRP for protein delivery

Content Provider	Royal Society of Chemistry (RSC)
Author	Hu, Y. Li, J. S. Xu, F. J. Zhao, N. N. Yang, W. T.
Copyright Year	2012
Abstract	The inherent hydroxyl groups on the porous polycaprolactone (PPCL) films (prepared by using poly(ethylene glycol) as the pore-forming agent) could be reacted with 2-bromoisobutyrate bromide to produce a sufficient concentration of surface-coupled atom transfer radical polymerization (ATRP) initiators for the subsequent surface-initiated ATRP of thermo-responsive N-isopropylacrylamide (NIPAAm) at room temperature. A kinetics study revealed that the chain growth of the grafted NIPAAm polymer (P(NIPAAm)) was very fast and consistent with a ‘controlled’ process. The graft copolymerization not only occurred on the porous film surface, but also took place into the film bulk. The resultant P(NIPAAm)-grafted PPCL (PPCL-g-P(NIPAAm)) films assumed a uniform and interconnected porous structure and exhibited a temperature-sensitive property with a lower critical solution temperature (LCST) of about 32 °C, not unlike pure P(NIPAAm). The release of bovine serum albumin (BSA as a model protein) from the PPCL-g-P(NIPAAm) films was characterized by an initial burst, followed by a sustained release. These thermo-responsive PPCL-g-P(NIPAAm) porous films are potentially useful in biomedical fields.
Starting Page	21257
Ending Page	21264
Page Count	8
File Format	HTM / HTML PDF
ISSN	09599428
Volume Number	22
Issue Number	39
Journal	Journal of Materials Chemistry
DOI	10.1039/c2jm34919a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	BSA Hydroxy group Polycaprolactone Ethylene glycol Atom-transfer radical-polymerization Polymer Bovine serum albumin Protein
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry

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