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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Odland, J. O. Thomassen, Y. Nieboer, E. Hofoss, D. Romanova, N. |
| Copyright Year | 2003 |
| Abstract | Research is described that constitutes an extension of an earlier paper (J. Environ. Monit., 2001, 3, 177–184), in which concentrations were measured in 263 human placentas of 11 essential elements (P, Ca, Mg, Cu, S, Na, Fe, Zn, K, Se, Mn) and 5 toxic elements (Ba, Sr, Pb, Ni, Cd). The additional data considered derive from earlier visits to 4 of the original 6 communities and 3 others, all but one of which are located in northern Norway and neighbouring areas of Russia. This more than doubled the number of placental samples available (263 to 571). Unfortunately, the personal, life-style and morphometric information obtained for the first study group was not available for the additional mothers. Country differences were evident for all elements except Ba, Fe and Zn; Cd, Cu, Mn, Na, Se, Ni, Pb, Sr and S were higher and K, P, Ca and Mg were lower in Russia (p < 0.03). Not unexpectedly, the highest median lead concentration was observed for the largest city in the western arctic region of Russia, namely Murmansk. Similarly, the higher median nickel level observed for Russia reflects the established observation that urinary nickel concentrations are higher in the Russian than in the Norwegian communities. Even though sampling was performed at different times of the year and before and after a 3-year interval in four centres, inter-collection differences were of relatively small magnitude and appear not to be linked to seasonal or temporal changes. Principal component analysis (PCA) confirmed the prominence of Factor 1, which grouped those metals that are known to form insoluble phosphate complexes and whose concentrations showed a dependence on gestational age and maternal smoking in the earlier study. It is concluded that PCA is a powerful statistical tool for exploring and identifying fundamental pathways and processes involved in governing the inorganic elemental composition of placental tissue. It also has the potential of identifying study limitations and quality assurance shortfalls. Further our findings show promise that placental concentrations of toxic elements may serve as an index of exposure and of nutritional intake for selected essential micro-elements. |
| Starting Page | 166 |
| Ending Page | 174 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 14640325 |
| Volume Number | 5 |
| Issue Number | 1 |
| Journal | Journal of Environmental Monitoring |
| DOI | 10.1039/b206776p |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Ba Cu PCA Environ Norway Russia Murmansk Monit Lead Original Six Nickel Norwegian language Principal component analysis Phosphate Correlation and dependence Gestational age Smoking and pregnancy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law |
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