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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Harrad, Stuart Abdallah, Mohamed Abou-Elwafa Collins, Chris Tilston, Emma |
| Copyright Year | 2012 |
| Abstract | An in vitro colon extended physiologically based extraction test (CEPBET) which incorporates human gastrointestinal tract (GIT) parameters (including pH and chemistry, solid-to-fluid ratio, mixing and emptying rates) was applied for the first time to study the bioaccessibility of brominated flame retardants (BFRs) from the 3 main GIT compartments (stomach, small intestine and colon) following ingestion of indoor dust. Results revealed the bioaccessibility of γ-HBCD (72%) was less than that for α- and β-isomers (92% and 80% respectively) which may be attributed to the lower aqueous solubility of the γ-isomer (2 μg L−1) compared to the α- and β-isomers (45 and 15 μg L−1 respectively). No significant change in the enantiomeric fractions of HBCDs was observed in any of the studied samples. However, this does not completely exclude the possibility of in vivo enantioselective absorption of HBCDs, as the GIT cell lining and bacterial flora – which may act enantioselectively – are not included in the current CE-PBET model. While TBBP-A was almost completely (94%) bioaccessible, BDE-209 was the least (14%) bioaccessible of the studied BFRs. Bioaccessibility of tri-hepta BDEs ranged from 32–58%. No decrease in the bioaccessibility with increasing level of bromination was observed in the studied PBDEs. |
| Starting Page | 3276 |
| Ending Page | 3283 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 14640325 |
| Volume Number | 14 |
| Issue Number | 12 |
| Journal | Journal of Environmental Monitoring |
| DOI | 10.1039/c2em30690e |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Large intestine Gastrointestinal tract PH Chemistry Small intestine Borland Database Engine Halogenation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law |
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