NDLI: The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: review and study update

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Research profileMax Costa

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The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: review and study update

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Secondary mobilisation of heavy metals in overbank sediments

¹⁴C and δ¹³C characteristics of organic matter and carbonate in saltmarsh sediments from south west Scotland

A 300 year history of lead contamination in northern French Alps reconstructed from distant lake sediment records

Paleolimnological assessment of Grove and Plow Shop Ponds, Ayer, Massachusetts, USA – A superfund site

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Development of an ombrotrophic peat bog (low ash) reference material for the determination of elemental concentrations

Identifying the sources and timing of ancient and medieval atmospheric lead pollution in England using a peat profile from Lindow bog, Manchester

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The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: review and study update

Content Provider	Royal Society of Chemistry (RSC)
Author	Priest, N. D.
Copyright Year	2004
Abstract	Until 1990 biokinetic studies of aluminium metabolism and biokinetics in man and other animals had been substantially inhibited by analytical and practical difficulties. Of these, the most important are the difficulties in differentiating between administered aluminium and endogenous aluminium–especially in body fluids and excreta and the problems associated with the contamination of samples with environmental aluminium. As a consequence of these it was not possible to detect small, residual body burdens of the metal following experimental administrations. Consequently, many believed aluminium to be quantitatively excreted within a short time of uptake in all, but renal-failure patients. Nevertheless, residual aluminium deposits in a number of different organs and tissues had been detected in normal subjects using a variety of techniques, including histochemical staining methods. In order to understand the origins and kinetics of such residual aluminium deposits new approaches were required. One approach taken was to employ the radioisotope 67Ga as a surrogate, but this approach has been shown to be flawed–a consequence of the different biological behaviours of aluminium and gallium. A second arose from the availability, in about 1990, of both 26Al–a rare and expensive isotope of aluminium–and accelerator mass spectrometry for the ultra-trace detection of this isotope. Using these techniques the basic features of aluminium biokinetics and bioavailability have been unravelled. It is now clear that some aluminium is retained in the body–most probably within the skeleton, and that some deposits in the brain. However, most aluminium that enters the blood is excreted in urine within a few days or weeks and the gastrointestinal tract provides an effective barrier to aluminium uptake. Aspects of the biokinetics and bioavailability of aluminium are described below.
Starting Page	375
Ending Page	403
Page Count	29
File Format	HTM / HTML PDF
ISSN	14640325
Volume Number	6
Issue Number	5
Journal	Journal of Environmental Monitoring
DOI	10.1039/b314329p
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Aluminium Metabolism Residual body Short Time Radionuclide Gallium Isotope Accelerator mass spectrometry Bioavailability Urine Gastrointestinal tract
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law

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The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: review and study update

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