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Analysis of whole blood by ICP-MS equipped with a high temperature total sample consumption system

Content Provider	Royal Society of Chemistry (RSC)
Author	Cañabate, Águeda García-Ruiz, Esperanza Resano, Martín Todolí, José-Luis
Copyright Year	2017
Abstract	In this work, the performance of a high temperature torch Integrated Sample Introduction System (hTISIS) using inductively coupled plasma mass spectrometry (ICP-MS) for the multi-element analysis of whole blood is evaluated. Two different quadrupole-based spectrometers were tested and the optimization studies were performed with a reference whole blood material. Sample dilution factor and hTISIS temperature were taken as the variables. The sample was introduced following two different procedures: continuous aspiration and air-segmentation. The optimum performance of the system in terms of both analytical figures of merit and accuracy was obtained for a hTISIS temperature of 200 °C and for either 1 : 10 or 1 : 25 dilution factors depending on the ICP-MS device used. An improvement in terms of sensitivity and detection limits was obtained with the hTISIS as compared to the conventional cyclonic spray chamber. Thus, for 1 : 25 diluted blood samples, the hTISIS improved the sensitivity by a factor ranging 2.0–4.5. Moreover, at 200 °C, the limits of detection for hTISIS at 200 °C were 1.1 to 8.4 times lower than those for the cyclonic spray chamber. This analytical parameter was in the ng L−1 range for the detected elements. Matrix effects in turn became less severe as the hTISIS temperature increased (from room temperature to 80 °C). All these results were obtained without a severe degradation of the fundamental plasma parameters. In fact, under optimum conditions BaO+/Ba+ and Ba2+/Ba+ signal ratios were 1.2% and 2.0%, respectively. The developed method was applied for the analysis of low volumes (ca. 2.5 μL) of real blood samples after a minimally invasive collection by volumetric absorptive microsampling. The hTISIS is an easy-to-implement sample introduction system that can be employed for the routine analysis using ICP-MS.
Starting Page	78
Ending Page	87
Page Count	10
File Format	HTM / HTML PDF
ISSN	02679477
Volume Number	32
Issue Number	1
Journal	Journal of Analytical Atomic Spectrometry
DOI	10.1039/c6ja00374e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Inductively coupled plasma mass spectrometry Mathematical optimization Blood plasma
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Analytical Chemistry

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