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Journal of Analytical Atomic Spectrometry Vol - 31 Issue - 8

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Journal of Analytical Atomic Spectrometry Vol -2

Update on the status of metrology for metalloproteins

Content Provider	Royal Society of Chemistry (RSC)
Author	Jakubowski, Norbert Swart, Claudia
Copyright Year	2016
Abstract	Metalloproteins, which represent about 30% of the total proteome, are often important markers for distinguishing between healthy and diseased states of patients. As such markers have become increasingly important in clinical diagnostics, some of these proteins are routinely analysed in clinical laboratories. Reliable and comparable results are the basis for the investigation of changes in the proteome due to different health conditions. Nevertheless, for many proteins the results achieved with different routine measurement procedures or in different laboratories vary widely, thus hampering medical insights and the development of treatments. Reference measurement procedures with results traceable to the International System of Units (SI) will also help to greatly improve the performance of routine measurement procedures and, this way, they support the understanding of changes in the metallome. This perspective will give an overview of the efforts during the last three years to achieve reliable quantification of metalloproteins. The analytes covered were chosen due to their importance in clinical diagnostics. Haemoglobin (HGB), transferrin (TRF), superoxide dismutase (SOD) or ceruloplasmin (CER), for example, can serve as markers for diseases such as Down's syndrome in prenatal diagnostics (e.g. SOD), inflammation (acute-phase proteins such as TRF) or deficiency diseases (e.g. HGB, TRF, and CER). Moreover, they are used for the control of treatment efficiency, e.g. total HGB as the most important marker for anaemia treatment or the glycosylated form of haemoglobin A (HBA1c) for the treatment of diabetes. On the other hand, selenoproteins, namely glutathione peroxidase (GPX), seem to play an important role in cancer prevention and in reducing the side effects of chemotherapies.
Starting Page	1756
Ending Page	1765
Page Count	10
File Format	HTM / HTML PDF
ISSN	02679477
Volume Number	31
Issue Number	9
Journal	Journal of Analytical Atomic Spectrometry
DOI	10.1039/c6ja00181e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Metalloprotein Proteome Metallome Hemoglobin Transferrin Thyrotropin-releasing hormone Superoxide dismutase Ceruloplasmin CER Computer Syndrome Inflammation Anemia Glycosylation Hemoglobin A Diabetes mellitus Glutathione peroxidase Cancer
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Analytical Chemistry

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Update on the status of metrology for metalloproteins

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Update on the status of metrology for metalloproteins