NDLI: Effect of adhesion and chemokine presentation on T-lymphocyte haptokinesis

Please wait, while we are loading the content...

Effect of adhesion and chemokine presentation on T-lymphocyte haptokinesis

Content Provider	Royal Society of Chemistry (RSC)
Author	Dominguez, George A. Hammer, Daniel A.
Copyright Year	2014
Abstract	Motility is critical for the function of T-lymphocytes. Motility in T-lymphocytes is driven by the occupancy of chemokine receptors by chemokines, and modulated by adhesive interactions. However, it is not well understood how the combination of adhesion and chemokine binding affects T-lymphocyte migration. We used microcontact printing on polymeric substrates to measure how lymphocyte migration is quantitatively controlled by adhesion and chemokine ligation. Focusing only on random motion, we found that T-lymphocytes exhibit biphasic motility in response to the substrate concentration of either ICAM-1 or VCAM-1, and generally display more active motion on ICAM-1 surfaces. Furthermore, we examined how the combination of the homeostatic chemokines CCL19 and CCL21 contribute to motility. By themselves, CCL19 and CCL21, ligands for CCR7, elicit biphasic motility, but their combination synergistically increases CCR7 mediated chemokinesis on ICAM-1. By presenting CCL21 with ICAM-1 on the surface with soluble CCL19, we observed random motion that is greater than what is observed with soluble chemokines alone. These data suggest that ICAM-1 has a greater contribution to motility than VCAM-1 and that both adhesive interactions and chemokine ligation work in concert to control T-lymphocyte motility.
Starting Page	862
Ending Page	873
Page Count	12
File Format	HTM / HTML PDF
ISSN	17579694
Volume Number	6
Issue Number	9
Journal	Integrative Biology
DOI	10.1039/c4ib00094c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Motility T cell Chemokine Microcontact printing Covalent bond ICAM-1 VCAM-1 Homeostasis CCL19 CCL21 CC chemokine receptors Chemokinesis
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effect of adhesion and chemokine presentation on T-lymphocyte haptokinesis †

The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged

6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7

Motile Human Neutrophils Sense Ligand Density Over Their Entire Contact Area

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing

Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARα Activation

A silent chemokine receptor regulates steady-state leukocyte homing in vivo.

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation.

Effect of adhesion and chemokine presentation on T-lymphocyte haptokinesis

Similar Documents

Effect of adhesion and chemokine presentation on T-lymphocyte haptokinesis †

The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged

6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7

Motile Human Neutrophils Sense Ligand Density Over Their Entire Contact Area

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing

Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARα Activation

A silent chemokine receptor regulates steady-state leukocyte homing in vivo.

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation.

Effect of adhesion and chemokine presentation on T-lymphocyte haptokinesis