NDLI: Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

Content Provider	Royal Society of Chemistry (RSC)
Author	Pretorius, Etheresia Kell, Douglas B.
Copyright Year	2014
Abstract	Most non-communicable diseases involve inflammatory changes in one or more vascular systems, and there is considerable evidence that unliganded iron plays major roles in this. Most studies concentrate on biochemical changes, but there are important biophysical correlates. Here we summarize recent microscopy-based observations to the effect that iron can have major effects on erythrocyte morphology, on erythrocyte deformability and on both fibrinogen polymerization and the consequent structure of the fibrin clots formed, each of which contributes significantly and negatively to such diseases. We highlight in particular type 2 diabetes mellitus, ischemic thrombotic stroke, systemic lupus erythematosus, hereditary hemochromatosis and Alzheimer's disease, while recognizing that many other diseases have co-morbidities (and similar causes). Inflammatory biomarkers such as ferritin and fibrinogen are themselves inflammatory, creating a positive feedback that exacerbates disease progression. The biophysical correlates we describe may provide novel, inexpensive and useful biomarkers of the therapeutic benefits of successful treatments.
Starting Page	486
Ending Page	510
Page Count	25
File Format	HTM / HTML PDF
ISSN	17579694
Volume Number	6
Issue Number	5
Journal	Integrative Biology
DOI	10.1039/c4ib00025k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Red blood cell Erythrocyte deformability Fibrinogen Polymerization Fibrin Diabetes mellitus Ischemia Systemic lupus erythematosus HFE hereditary haemochromatosis Ferritin
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Biophysics

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