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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Gerhardt, Matthias Beta, Carsten Pfannes, Eva K. B. Anielski, Alexander |
| Copyright Year | 2013 |
| Abstract | Cyclic GMP (cGMP) is a ubiquitous second messenger in eukaryotic cells. It is assumed to regulate the association of myosin II with the cytoskeleton of motile cells. When cells of the social amoeba Dictyostelium discoideum are exposed to chemoattractants or to increased osmotic stress, intracellular cGMP levels rise, preceding the accumulation of myosin II in the cell cortex. To directly investigate the impact of intracellular cGMP on cytoskeletal dynamics in a living cell, we released cGMP inside the cell by laser-induced photo-cleavage of a caged precursor. With this approach, we could directly show in a live cell experiment that an increase in intracellular cGMP indeed induces myosin II to accumulate in the cortex. Unexpectedly, we observed for the first time that also the amount of filamentous actin in the cell cortex increases upon a rise in the cGMP concentration, independently of cAMP receptor activation and signaling. We discuss our results in the light of recent work on the cGMP signaling pathway and suggest possible links between cGMP signaling and the actin system. |
| Starting Page | 1456 |
| Ending Page | 1463 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 17579694 |
| Volume Number | 5 |
| Issue Number | 12 |
| Journal | Integrative Biology |
| DOI | 10.1039/c3ib40109j |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Cyclic guanosine monophosphate Eukaryote Myosin Cytoskeleton Motility Amoeba Dictyostelium discoideum Osmotic shock Cell cortex Actin Cyclic adenosine monophosphate Cell surface receptor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Biophysics |
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