NDLI: Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

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Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets

In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity

Diacylglycerol kinase zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow

RhoA-induced cytoskeletal tension controls adaptive cellular remodeling to mechanical signaling

Encapsulation of angiogenic monocytes using bio-spraying technology

Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size

A plant virus substrate induces early upregulation of BMP2 for rapid bone formation

Chromatin accessibility at the HIV LTR promoter sets a threshold for NF-κB mediated viral gene expression

Monitoring of the prostate tumour cells redox state and real-time proliferation by novel biophysical techniques and fluorescent staining

Preparation, characterization, and surface immobilization of native vesicles obtained by mechanical extrusion of mammalian cells

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Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhu, Shijun Khuri, Fadlo R. Zhang, Hongzheng Sun, Aiming Arrendale, Richard F. Lin, Xiaoqian Chen, Zhuo G. Snyder, James P. Culver, Deborah Fu, Haian Reddy, Prabhakar Shoji, Mamoru Evers, Taylor J. Shin, Dong M. Moore, Terry W. Morii, Nao Mancini, Alessandra Howard, Randy B. Sica, Gabriel
Copyright Year	2012
Abstract	Objectives are to examine the efficacy, pharmacokinetics, and toxicology of a synthetic curcumin analog EF31 in head and neck squamous cell carcinoma. The synthesis of EF31 was described for the first time. Solubility of EF24 and EF31 was compared using nephelometric analysis. Human head and neck squamous cell carcinoma Tu212 xenograft tumors were established in athymic nude mice and treated with EF31 i.p. once daily five days a week for about 5–6 weeks. The long term effect of EF31 on the NF-κB signaling system in the tumors was examined by Western blot analysis. EF31 at 25 mg kg−1, i.p. inhibited tumor growth almost completely. Solubilities of EF24 and EF31 are <10 and 13 μg mL−1 or <32 and 47 μM, respectively. The serum chemistry profiles of treated mice were within the limits of normal, they revealed a linear increase of Cmax. EF31 decreased the level of phosphorylation of NF-κB p65. In conclusion, the novel synthetic curcumin analog EF31 is efficacious in inhibiting the growth of Tu212 xenograft tumors and may be useful for treating head and neck squamous cell carcinoma. The long term EF31 treatment inhibited NF-κB p65 phosphorylation in xenografts, implicating downregulation of cancer promoting transcription factors such as angiogenesis and metastasis.
Starting Page	633
Ending Page	640
Page Count	8
File Format	HTM / HTML PDF
ISSN	17579694
Volume Number	4
Issue Number	6
Journal	Integrative Biology
DOI	10.1039/c2ib20007d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Pharmacokinetics Toxicology Curcumin Carcinoma Human head Xenotransplantation Nude mouse NF-κB Western blot Chemistry Cmax (pharmacology) Phosphorylation Cancer Angiogenesis Metastasis
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Biophysics

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Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

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Identification of SLC2A3 as a prognostic indicator correlated with the NF-κB/EMT axis and immune response in head and neck squamous cell carcinoma.

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Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

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