NDLI: The mass-action law based algorithms for quantitative econo-green bio-research

Please wait, while we are loading the content...

The mass-action law based algorithms for quantitative econo-green bio-research

Content Provider	Royal Society of Chemistry (RSC)
Author	Chou, Ting-Chao
Copyright Year	2011
Abstract	The relationship between dose and effect is not random, but rather governed by the unified theory based on the median-effect equation (MEE) of the mass-action law. Rearrangement of MEE yields the mathematical form of the Michaelis–Menten, Hill, Henderson–Hasselbalch and Scatchard equations of biochemistry and biophysics, and the median-effect plot allows linearization of all dose-effect curves regardless of potency and shape. The “median” is the universal common-link and reference-point for the 1st-order to higher-order dynamics, and from single-entities to multiple-entities and thus, it allows the all for one and one for all unity theory to “integrate” simple and complex systems. Its applications include the construction of a dose-effect curve with a theoretical minimum of only two data points if they are accurately determined; quantification of synergism or antagonism at all dose and effect levels; the low-dose risk assessment for carcinogens, toxic substances or radiation; and the determination of competitiveness and exclusivity for receptor binding. Since the MEE algorithm allows the reduced requirement of the number of data points for small size experimentation, and yields quantitative bioinformatics, it points to the deterministic, efficient, low-cost biomedical research and drug discovery, and ethical planning for clinical trials. It is concluded that the contemporary biomedical sciences would greatly benefit from the mass-action law based “Green Revolution”.
Starting Page	548
Ending Page	559
Page Count	12
File Format	HTM / HTML PDF
ISSN	17579694
Volume Number	3
Issue Number	5
Journal	Integrative Biology
DOI	10.1039/c0ib00130a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Hill Henderson Hasselbalch Scatchard Biochemistry Biophysics Estrogen receptor Algorithm Bioinformatics Drug discovery Green Revolution
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The mass-action law based algorithm for cost-effective approach for cancer drug discovery and development

Significance of microRNA targeted estrogen receptor in male fertility

Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia

Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands

Levoglucosenone: Bio-Based Platform for Drug Discovery

THE pK' OF THE HENDERSON-HASSELBALCH EQUATION FOR HYDRION CONCENTRATION OF SERUM

Development of subtype-selective oestrogen receptor-based therapeutics.

Tethered Indoles as Functionalizable Ligands for the Estrogen Receptor

Significance of microRNA targeted estrogen receptor in male fertility

The mass-action law based algorithms for quantitative econo-green bio-research

Similar Documents

The mass-action law based algorithm for cost-effective approach for cancer drug discovery and development

Significance of microRNA targeted estrogen receptor in male fertility

Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia

Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands

Levoglucosenone: Bio-Based Platform for Drug Discovery

THE pK' OF THE HENDERSON-HASSELBALCH EQUATION FOR HYDRION CONCENTRATION OF SERUM

Development of subtype-selective oestrogen receptor-based therapeutics.

Tethered Indoles as Functionalizable Ligands for the Estrogen Receptor

Significance of microRNA targeted estrogen receptor in male fertility

The mass-action law based algorithms for quantitative econo-green bio-research