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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Gallinat, Stefan Wenck, Horst Knott, Anja Ruetze, Martin Deppert, Wolfgang |
| Copyright Year | 2010 |
| Abstract | Precise knowledge of the frequency and localization of epidermal stem cells within skin tissue would further our understanding of their role in maintaining skin homeostasis. As a novel approach we used the recently developed method of multi epitope ligand cartography, applying a set of described putative epidermal stem cell markers. Bioinformatic evaluation of the data led to the identification of several discrete basal keratinocyte populations, but none of them displayed the complete stem cell marker set. The distribution of the keratinocyte populations within the tissue was remarkably heterogeneous, but determination of distance relationships revealed a population of quiescent cells highly expressing p63 and the integrins α6/β1 that represent origins of a gradual differentiation lineage. This population comprises about 6% of all basal cells, shows a scattered distribution pattern and could also be found in keratinocyte holoclone colonies. The data suggest that this population identifies interfollicular epidermal stem cells. |
| Starting Page | 241 |
| Ending Page | 249 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 17579694 |
| Volume Number | 2 |
| Issue Number | 5-6 |
| Journal | Integrative Biology |
| DOI | 10.1039/b926147h |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Homeostasis Epitope Ligand Cartography Stem cell Keratinocyte TP63 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry Biophysics |
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