Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Arning, Jürgen Bottin-Weber, Ulrike Müller, Anja Ranke, Johannes Pitner, William-Robert Stolte, Stefan Welz-Biermann, Urs Jastorff, Bernd |
| Copyright Year | 2007 |
| Abstract | To enlarge the restricted knowledge about the hazard potentials of ionic liquids to men and the environment we have concentrated on systematically analysing the effects of 7 head groups, 10 side chains (mainly containing functional groups) and 4 anions on cytotoxicity. For our investigations, we used the promyelotic leukemia rat cell line IPC-81 as test system, with the reduction of the WST-1 dye as an indicator of cell viability. Our results show that most of the tested 100 ionic liquids generally exhibit a low cytotoxicity compared to previously investigated ionic liquids in consequence of their polar ether, hydroxyl and nitrile functional groups within the side chains. Those functional groups hamper cellular uptake by membrane diffusion and reduce lipophilicity based interactions with the cell membrane. In general, a low influence of the head group and a clear anion effect of the [(CF3SO2)2N]− anion could be observed. Furthermore, we could confirm the general dependency between ionic liquid cation lipophilicity and cytotoxicity using a HPLC derived lipophilicity parameter. For one head group and for one side chain, deviations were obtained concerning this general dependency. This can be interpreted as a first hint for a more specific mode of action for these structural elements. |
| Starting Page | 760 |
| Ending Page | 767 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 14639262 |
| Volume Number | 9 |
| Issue Number | 7 |
| Journal | Green Chemistry |
| DOI | 10.1039/b615326g |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Subscribed |
| Subject Keyword | Cytotoxicity Leukemia Dye Ether Hydroxy group Nitrile Diffusion Lipophilicity Cell membrane Ion Ionic liquid High-performance liquid chromatography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Pollution |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|