NDLI: Bioactive properties of commercialised pomegranate (<i>Punica granatum</i>) juice: antioxidant, antiproliferative and enzyme inhibiting activities

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Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities

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Food & Function Vol - 6 Issue - 5

Food & Function Vol - 6 Issue - 4

Food & Function Vol - 6 Issue - 3

Food & Function Vol - 6 Issue - 2

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities

Content Provider	Royal Society of Chemistry (RSC)
Author	Les, Francisco Prieto, Jose M. Arbonés-Mainar, Jose Miguel Valero, Marta Sofía López, Víctor
Copyright Year	2015
Abstract	Pomegranate juice and related products have long been used either in traditional medicine or as nutritional supplements claiming beneficial effects. Although there are several studies on this food plant, only a few studies have been performed with pomegranate juice or marketed products. The aim of this work is to evaluate the antioxidant effects of pomegranate juice on cellular models using hydrogen peroxide as an oxidizing agent or DPPH and superoxide radicals in cell free systems. The antiproliferative effects of the juice were measured on HeLa and PC-3 cells by the MTT assay and pharmacologically relevant enzymes (cyclooxygenases, xanthine oxidase, acetylcholinesterase and monoamine oxidase A) were selected for enzymatic inhibition assays. Pomegranate juice showed significant protective effects against hydrogen peroxide induced toxicity in the Artemia salina and HepG2 models; these effects may be attributed to radical scavenging properties of pomegranate as the juice was able to reduce DPPH and superoxide radicals. Moderate antiproliferative activities in HeLa and PC-3 cancer cells were observed. However, pomegranate juice was also able to inhibit COX-2 and MAO-A enzymes. This study reveals some mechanisms by which pomegranate juice may have interesting and beneficial effects in human health.
Starting Page	2049
Ending Page	2057
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	6
Journal	Food & Function
DOI	10.1039/c5fo00426h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DPPH MTT Artemia HeLa Pomegranate juice Traditional medicine Antioxidant Peroxide Redox Superoxide PC3 MTT assay Xanthine Xanthine oxidase Acetylcholinesterase Monoamine oxidase Artemia salina Pomegranate Cancer Prostaglandin-endoperoxide synthase 2
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities

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