NDLI: Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co-culture model

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Food & Function Vol - 5 Issue - 3

Food & Function Vol - 5 Issue - 2

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co-culture model

Content Provider	Royal Society of Chemistry (RSC)
Author	Jailani, Fadhilah Williamson, Gary
Copyright Year	2014
Abstract	Solubility and matrix play an important role in the gut lumen in delivering bioactive compounds to the absorptive surface of enterocytes. The purpose of this study was to determine the effect of certain commonly consumed lipids, soybean, olive and corn oil, on the transport and conjugation of flavonols (myricetin, quercetin, kaempferol and galangin) using the conjugation-competent co-cultured Caco-2/HT29-MTX intestinal cell monolayer model. To enable identification and quantification of conjugates, each flavonol was enzymatically glucuronidated or sulphated, then analysed by HPLC with triple quadrupole mass spectrometric detection. Quantification showed large differences in mass spectrometric peak area response factors between the aglycones and many of the conjugates, with galangin-sulphate for example ionising ∼15-fold better than galangin. Flavonol aglycones and conjugates were transported to the basolateral side of Caco-2/HT29-MTX co-cultures. The total amount of methyl, sulphate and glucuronide conjugates was in the order: galangin > quercetin > kaempferol > myricetin. All oils inhibited the transport and conjugation of galangin, the most hydrophobic flavonol, whereas they increased the sulphation, and to some extent glucuronidation, of quercetin and kaempferol. The results show that the lipid matrix has the potential to modify both transport and conjugation of dietary flavonols, but that the effect depends upon the structure and hydrophobicity.
Starting Page	653
Ending Page	662
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	4
Journal	Food & Function
DOI	10.1039/c3fo60691k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Extracellular matrix Thylakoid Corn oil Quercetin Kaempferol Galangin Caco-2 NCI-60 Flavonols Glucuronidation High-performance liquid chromatography Quadrupole mass analyzer Glucuronide Amino acid Sulfation Lipid Hydrophobe
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co-culture model

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