NDLI: <i>Hibiscus sabdariffa</i> L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice

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Food & Function Vol - 4 Issue - 3

Food & Function Vol - 4 Issue - 2

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice

Content Provider	Royal Society of Chemistry (RSC)
Author	Canales-Aguirre, Arturo Alejandro Villalpando-Arteaga, Edgar Vinicio Mateos-Díaz, Juan Carlos Rodríguez-González, Jorge Alberto Gálvez-Gastélum, Francisco Javier Márquez-Aguirre, Ana Laura Esquivel-Solís, Hugo Mendieta-Condado, Edgar
Copyright Year	2013
Abstract	The growing incidence of obesity is a worldwide public health problem leading to a risk factor for non-alcoholic fatty liver disease, which extends from steatosis to steatohepatitis and cirrhosis. We investigated whether the aqueous extract of Hibiscus sabdariffa L. (Hs) reduces body weight gain and protects the liver by improving lipid metabolism in high fat diet-induced obese C57BL/6NHsd mice. We found that oral administration of the Hs extract reduced fat tissue accumulation, diminished body weight gain and normalized the glycemic index as well as reduced dyslipidemia compared to the obese mice group that did not receive Hs treatment. In addition, Hs treatment attenuated liver steatosis, down-regulated SREBP-1c and PPAR-γ, blocked the increase of IL-1, TNF-α mRNA and lipoperoxidation and increased catalase mRNA. Our results suggest that the anti-obesity, anti-lipidemic and hepatoprotective effects of the Hs extract are related to the regulation of PPAR-γ and SREBP-1c in the liver.
Starting Page	618
Ending Page	626
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	4
Issue Number	4
Journal	Food & Function
DOI	10.1039/c3fo30270a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Obesity Public health Non-alcoholic fatty liver disease Steatosis Steatohepatitis Cirrhosis Roselle (plant) Liver Lipid Metabolism Dyslipidemia Peroxisome proliferator-activated receptor gamma Interleukin-1 family Tumor necrosis factor alpha Messenger RNA Catalase Hepatoprotection
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice

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Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice