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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Boveris, Alberto Monserrat, Alberto J. Ossani, Georgina P. Repetto, Marisa G. |
| Copyright Year | 2013 |
| Abstract | Weanling rats fed a choline-deficient diet develop kidney oxidative damage, tubular and cortical kidney necrosis, renal failure and animal death. The effect of dietary menhaden oil was assayed on the mentioned sequence correlating oxidative stress with renal structure and function. Rats were fed ad libitum 4 different diets: (a) a choline-deficient diet with corn oil and sunflower hydrogenated oil as a source of fatty acids; (b) the same diet supplemented with choline; (c) a choline-deficient diet with menhaden oil as a source of fatty acids; and (d) the previous diet supplemented with choline. Animals were sacrificed at days 0, 2, 4 and 7. The histopathological study of the kidneys showed that renal necrosis was only observed at day 7 in choline-deficient rats receiving the vegetable oil diet, simultaneously with increased creatinine plasma levels. Homogenate chemiluminescence (BOOH-initiated chemiluminescence) and phospholipid oxidation indicate the development of oxidative stress and damage in choline-deficient rats fed vegetable oils as well as the protective effect of menhaden oil. Rats fed with the fish oil diet showed that oxidative stress and damage develop later, as compared with vegetable oil, with no morphological damage during the experimental period. |
| Starting Page | 448 |
| Ending Page | 452 |
| Page Count | 5 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 4 |
| Issue Number | 3 |
| Journal | Food & Function |
| DOI | 10.1039/c2fo30229b |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Weanling Kidney Necrosis Menhaden Oxidative stress Ad libitum Corn oil Sunflower oil Hydrogenation Choline Vegetable oil Creatinine Blood plasma Chemiluminescence Phospholipid Fish oil |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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